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First-line immune-based combinations or sunitinib in favorable-risk metastatic renal cell carcinoma: a real-world retrospective comparison from the ARON-1 study.
Cancer Immunol Immunother
January 2025
Oncology Unit, Macerata Hospital, Macerata, Italy.
Introduction: Renal cell carcinoma (RCC) is one of the most common types of urogenital cancer. The introduction of immune-based combinations, including dual immune-checkpoint inhibitors (ICI) or ICI plus tyrosine kinase inhibitors (TKIs), has radically changed the treatment landscape for metastatic RCC, showing varying efficacy across different prognostic groups based on the International Metastatic RCC Database Consortium (IMDC) criteria.
Materials And Methods: This retrospective multicenter study, part of the ARON-1 project, aimed to evaluate the outcomes of favorable-risk metastatic RCC patients treated with immune-based combinations or sunitinib.
Impact of Social Determinants of Health on Primary Adherence of Oral Anticoagulants Among Patients with Newly Diagnosed Atrial Fibrillation.
Cardiol Ther
January 2025
Advocate Aurora Research Institute, Advocate Health, 945 N 12th St, Milwaukee, WI, 53233, USA.
Introduction: Oral anticoagulants (OAC) reduce the risk of stroke among patients with atrial fibrillation (AF). However, adherence remains suboptimal. We focused on primary nonadherence to OAC and its associations with patient characteristics-specifically social determinants of health collected in electronic health records (EHR).
View Article and Find Full Text PDFHealth state utilities associated with invasive pneumococcal disease, pneumonia, and recurrent acute otitis media in young children.
Qual Life Res
January 2025
MRL, Merck & Co., Inc., Rahway, NJ, USA.
Purpose: Cost-utility analyses examining the value of new vaccines for pneumococcal disease will require health state utilities as inputs. Existing utilities for pneumococcal infections in young children are limited. The purpose of this study was to estimate health state utilities associated with pneumococcal infections in young children.
View Article and Find Full Text PDFClinical Manifestations.
Alzheimers Dement
December 2024
University of Virginia, Charlottesville, VA, USA.
Background: There is mounting evidence that difficulties with sleep including insomnia, sleep quality, and sleep fragmentation contribute to Alzheimer's disease risk including formation of beta-amyloid. Disrupted sleep is common in people with dementia (PWD). Primary unpaid caregivers (CGs) of PWD may also have disrupted sleep as a result of their caregiving roles.
View Article and Find Full Text PDFInvestigation and Analysis of Disaster Preparedness among Nurses in Chinese Non-First-tier (Inland) Cities: A Case Study from Yongcheng City, Henan Province.
Disaster Med Public Health Prep
January 2025
Department of Neurosurgery, Shanghai East Hospital, Tongji University School of Medicine, Shanghai200120, China.
Objectives: Compared with first-tier cities in China that are of abundant funds and resources like legions of high-level hospitals, the degree of nurses' disaster nursing preparedness in non-first-tier cities (inland) is relatively lower. For example, nurses' knowledge reserve of specific disasters is not comprehensive enough. And nurses are diffident when it comes to the skills of handling disaster rescue.
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