AI Article Synopsis
- The study aimed to compare the effectiveness and consistency of two-bed single-photon emission computed tomography/computed tomography (TBSCT) images against conventional planar bone scintigraphy (PBS) for diagnosing bone metastasis in patients with solid tumors.
- Results showed that TBSCT images had a higher level of agreement between different interpreters and were less likely to yield inconclusive results compared to PBS; specifically, TBSCT demonstrated significantly better sensitivity and accuracy, particularly for patients with non-breast cancers.
- In conclusion, TBSCT not only had better reproducibility but also reduced inconclusive findings, leading to improved diagnostic capabilities for patients with solid tumors overall, with a notable advantage for those who do not have
Article Abstract
Objective: To evaluate the reproducibility and diagnostic performance of two-bed single-photon emission computed tomography/computed tomography (SPECT/CT) images (TBSCT), compared to conventional planar bone scintigraphy (PBS) for the diagnosis of osseous metastasis.
Methods: Patients with known solid tumor, referred to perform PBS, were included in this prospective study. PBS acquisition was followed by TBSCT images, covering at least the chest, abdomen and pelvis. Each modality was interpreted during a separate session by two independent nuclear medicine physicians with 12- and 3-year experience. Reference standard was formulated on the basis of subsequent clinical/imaging/histopathological evidence.
Results: One-hundred and six patients were finally included in our study. A moderate agreement between the two physicians was seen for PBS readings [k = 0.74; 95% confidence interval (CI), 0.61-0.86] which increased to 0.87 (95% CI, 0.77-0.96) for TBSCT. PBS readings were inconclusive in 29/106, compared to 6 for TBSCT. For each reader, TBSCT showed significantly greater sensitivity and accuracy compared to PBS. There was no significant difference in the sensitivity, specificity or accuracy of both modalities in patients with the breast cancer group, whereas TBSCT images have shown significant higher sensitivity and accuracy compared to PBS (P = 0.02 and 0.002, respectively) in nonbreast cancer patients.
Conclusion: TBSCT demonstrated higher reproducibility and significantly decreased the proportion of inconclusive readings of PBS. TBSCT resulted in significant gain in sensitivity and accuracy in the unselected group of patients with solid tumors. However, that gain may be better appreciated in patients with nonbreast cancer.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1097/MNM.0000000000001353 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Relevance of Sentinel Nodes in Atypical Territories in Surgically Treated Patients With T1-2N0 Oral Squamous Cell Carcinoma.
Head Neck
January 2025
Service of Oral and Maxillofacial Surgery, Hospital Universitari Vall d'Hebron, Universitat Autònoma de Barcelona, Barcelona, Spain.
Objectives: To assess the usefulness of sentinel lymph node biopsy (SLNB) in patients with early-stage oral squamous cell carcinoma (OSCC).
Materials And Methods: Seventy-five patients (mean age 62 years) diagnosed with cT1-2 N0 underwent SLNB with Tc, lymphoscintigraphy/SPECT-CT, and gamma probe detection with intraoperative histological examination of the resected sentinel lymph nodes (SLNs). Elective neck dissection was performed during the same surgical procedure of primary tumor resection when malignant deposits were detected microscopically.
Comprehensive Non-invasive Versus Invasive Approach to Evaluate Cardiac Allograft Vasculopathy in Heart Transplantation: The CCTA-HTx Study.
Circ Cardiovasc Imaging
January 2025
Cardiovascular Center Aalst, Onze-Lieve-Vrouwziekenhuis (OLV) Clinic, Aalst, Belgium (M. Belmonte, P.P., M.M.V., M. Beles, H.O., R.S., G.E., M.S., R.D., W.H., J.V.K., J.B., M.V.).
Background: Coronary computed tomography angiography (CCTA) is emerging as a valuable tool for noninvasive surveillance of cardiac allograft vasculopathy (CAV) in patients with heart transplant (HTx). We assessed the diagnostic performance of a comprehensive CCTA-based approach compared with the invasive reference, which includes invasive coronary angiography, intravascular ultrasound, and fractional flow reserve, for detecting CAV.
Methods: This was a multicenter prospective study including 37 patients with HTx who underwent CCTA, invasive coronary angiography, intravascular ultrasound, and fractional flow reserve.
Genomic Prediction of Individual Inbreeding Levels for the Management of Genetic Diversity in Populations With Small Effective Size.
Mol Ecol Resour
January 2025
Unit of Animal Genomics, GIGA-R & Faculty of Veterinary Medicine, University of Liège, Liège, Belgium.
In populations of small effective size (N), such as those in conservation programmes, companion animals or livestock species, inbreeding control is essential. Homozygosity-by-descent (HBD) segments provide relevant information in that context, as they allow accurate estimation of the inbreeding coefficient, provide locus-specific information and their length is informative about the "age" of inbreeding. Our objective was to evaluate tools for predicting HBD in future offspring based on parental genotypes, a problem equivalent to identifying segments identical-by-descent (IBD) among the four parental chromosomes.
View Article and Find Full Text PDFDiagnostic accuracy of qualitative gastric ultrasound assessment for detecting high gastric fluid volume in children: a prospective randomised study.
Anaesthesia
January 2025
Department of Anaesthesia and Intensive Care, Hospices Civils de Lyon, Femme Mère Enfant Hospital, Bron, France.
Introduction: The diagnostic accuracy of gastric ultrasound in children has not been assessed thoroughly. We aimed to determine the sensitivity and specificity in children of a qualitative ultrasound examination of the gastric antrum in the supine 45° semi-recumbent position and a clinical algorithm for detecting a gastric fluid volume > 1.25 ml.
View Article and Find Full Text PDFBankart lesions, or anterior-inferior glenoid labral tears, are diagnostically challenging on standard MRIs due to their subtle imaging features-often necessitating invasive MRI arthrograms (MRAs). This study develops deep learning (DL) models to detect Bankart lesions on both standard MRIs and MRAs, aiming to improve diagnostic accuracy and reduce reliance on MRAs. We curated a dataset of 586 shoulder MRIs (335 standard, 251 MRAs) from 558 patients who underwent arthroscopy.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!