AI Article Synopsis
- Leonhard's experience at the Erlangen University Psychiatric and Mental Clinic exposed him to both acute and chronic schizophrenia, influencing his later classification system for the disorder.
- There is insufficient evidence to claim that Leonhard had ADHD, but his reluctance to discuss social-psychiatric issues relates to his early work with the controversial 'Erlangen system' and its affiliation with Nazi ideology.
- His ambiguous involvement with National Socialism and challenges in 1951 to maintain his position in a divided Germany highlight the complexities of his professional life during that era.
Article Abstract
The Erlangen University Psychiatric and Mental Clinic was an annexe to the Erlangen Mental Asylum, so when Leonhard worked there he became acquainted with acute and chronic stages of schizophrenia. This can be viewed as a decisive impulse for his later differentiated classification of types of schizophrenia. The suspicion that Leonhard suffered from attention deficit hyperactivity disorder cannot be supported. His reticence concerning social-psychiatric aspects is analysed in the context of his early professional contact with the 'Erlangen system' of open care and its Nazi perversion. Leonhard's role in National Socialism is still uncertain. His unsuccessful attempts to retain the Erlangen Chair of Psychiatry and Mental Illness in 1951 can be viewed as his first difficulty in the tensions between West Germany and East Germany.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1177/0957154X20978836 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
A SAM-key domain required for enzymatic activity of the Fun30 nucleosome remodeler.
Life Sci Alliance
September 2023
DNA Replication and Genome Integrity, Max Planck Institute of Biochemistry, Martinsried, Germany
Article Synopsis
- Fun30 is a nucleosome remodeler involved in DNA repair and gene silencing, but its mechanisms are not well understood.
- A conserved domain called SAM-key was identified, which is crucial for Fun30’s function; deleting it results in defects similar to a mutant form of the protein.
- Structural modeling and experiments show that the SAM-key helix interacts with other protein regions to regulate ATPase activity, essential for nucleosome remodeling.
Establishment and function of chromatin organization at replication origins.
Nature
April 2023
Biomedical Center Munich (BMC), Division of Molecular Biology, Faculty of Medicine, Ludwig-Maximilians-Universität in Munich, Martinsried, Germany.
The origin recognition complex (ORC) is essential for initiation of eukaryotic chromosome replication as it loads the replicative helicase-the minichromosome maintenance (MCM) complex-at replication origins. Replication origins display a stereotypic nucleosome organization with nucleosome depletion at ORC-binding sites and flanking arrays of regularly spaced nucleosomes. However, how this nucleosome organization is established and whether this organization is required for replication remain unknown.
View Article and Find Full Text PDFDNA Double Strand Break Repair and Its Control by Nucleosome Remodeling.
Front Genet
January 2022
Resarch Group DNA Replication and Genome Integrity, Max Planck Institute of Biochemistry, Martinsried, Germany.
DNA double strand breaks (DSBs) are repaired in eukaryotes by one of several cellular mechanisms. The decision-making process controlling DSB repair takes place at the step of DNA end resection, the nucleolytic processing of DNA ends, which generates single-stranded DNA overhangs. Dependent on the length of the overhang, a corresponding DSB repair mechanism is engaged.
View Article and Find Full Text PDFA CCaMK-CYCLOPS-DELLA Complex Activates Transcription of RAM1 to Regulate Arbuscule Branching.
Curr Biol
April 2016
Faculty of Biology, Genetics, Biocenter Martinsried, LMU Munich, Großhaderner Strasse 2-4, 82152 Martinsried, Germany. Electronic address:
Intracellular arbuscular mycorrhiza symbiosis between plants and glomeromycotan fungi leads to formation of highly branched fungal arbuscules that release mineral nutrients to the plant host. Their development is regulated in plants by a mechanistically unresolved interplay between symbiosis, nutrient, and hormone (gibberellin) signaling. Using a positional cloning strategy and a retrotransposon insertion line, we identify two novel alleles of Lotus japonicus REDUCED ARBUSCULAR MYCORRHIZA1 (RAM1) encoding a GRAS protein.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!