Electrosynthesis of Quinazolines and Quinazolinones via an Anodic Direct Oxidation C(sp)-H Amination/C-N Cleavage of Tertiary Amine in Aqueous Medium.

Zhenghong Zhou Kangfei Hu Jiawei Wang Zhibin Li Yan Zhang Zhenggen Zha Zhiyong Wang

ACS Omega

Hefei National Laboratory for Physical Sciences at Microscale, CAS Key Laboratory of Soft Matter Chemistry & Center for Excellence in Molecular Synthesis of Chinese Academy of Sciences, Collaborative Innovation Center of Suzhou Nano Science and Technology & School of Chemistry and Materials Science, University of Science and Technology of China, Hefei, Anhui 230026, People's Republic of China.

Published: December 2020

An electrochemical synthesis for quinazolines and quinazolinones was developed via a C(sp)-H amination/C-N cleavage by virtue of the anodic oxidation. The reaction can be carried out in aqueous media under mild conditions to afford the desired products with high yields. The reaction mechanism was proposed after detailed investigation.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7745442	PMC
http://dx.doi.org/10.1021/acsomega.0c04865	DOI Listing

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