Background: can asymptomatically colonize the human anterior nares and skin, and nasal colonization by this bacterium represents a potential risk for development of invasive infections. The aim of this study was to determine the prevalence of nasal carriage among healthcare workers and students attending a university hospital and to characterize the isolates phenotypically and molecularly.
Methods: A cross-sectional study was performed with 324 volunteers. Cultures from nasal samples were obtained and isolates were characterized according to their antimicrobial susceptibility profile and four virulence factors-encoding genes. MRSA isolates were characterized regarding their oxacillin/cefoxitin susceptibility, SCC and REP-PCR types. Potential risks for and MRSA carriage were analyzed.
Results: Of 324 nasal samples, 42.9% were identified as , of which 28.8% were MRSA. carriers were significantly higher in males and students (OR = 2.898, 95%CI 1.553-5.410); however, no variables were associated with MRSA carriage. All isolates were susceptible to vancomycin and the highest rate of resistance was observed for penicillin (90.6%). All isolates harbored the gene, and 97.8%, the gene; 15.8% and 6.5% were positive for and genes, respectively. Among MRSA isolates, 45% carried the gene but were phenotypically susceptible to oxacillin/cefoxitin; two harbored the and none had genes. All MRSAs were distributed into six SCC types and type I (62.5%) was the most frequent. REP-PCR typing identified four main clusters among MRSA isolates.
Conclusion: High prevalence of healthcare workers and students were identified as nasal carriers of exhibiting different antimicrobial resistance profiles, including -positive oxacillin-susceptible (OS-MRSA) and the presence of virulence-encoding genes. Both cohorts may represent potential sources for the emergence of a successful strain highly adapted to the hospital environment.
Download full-text PDF |
Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7732402 | PMC |
| http://dx.doi.org/10.1155/2020/3808036 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Real-world experience with nucleos(t)ide analogue therapy and patient survival rates in chronic viral hepatitis B treatment centers in Eritrea.
Sci Rep
January 2025
Division of National Control of Communicable Diseases, Ministry of Health, Asmara, Eritrea.
Real-world data on treatment outcomes or the quality of large-scale chronic hepatitis B (CHB) treatment programs in sub-Saharan Africa (SSA) is extremely difficult to obtain. In this study, we aimed to provide data on the prevalence and incidence of mortality, loss to follow-up (LFTU), and their associated factors in patients with CHB in three treatment centres in Eritrea. Additional information includes baseline clinical profiles of CHB patients initiated on nucleos(t)ide analogue (NUCs) along with a comparison of treatment with Tenofovir disoproxil fumarate (TDF) vs.
View Article and Find Full Text PDFComparing COVID-19 literacy and vaccine hesitancy among health care workers, including oral health professionals, in Japan.
BDJ Open
January 2025
Fukuoka Nursing College, Graduate School of Nursing, 2-15-1 Tamura, Sawara-ku, Fukuoka, 814-0193, Japan.
Background: Oral health professionals should have good COVID-19 vaccine literacy as should physicians and nurses. However, little is known about COVID-19 literacy and vaccine hesitancy among oral health professionals in Japan.
Aims: This study aimed to investigate the status of COVID-19 literacy and vaccine hesitancy among oral health professionals by comparing them with other healthcare workers (HCWs).
The well-being of polish general practitioners during the COVID-19 pandemic-cross-sectional questionnaire-based study.
BMC Prim Care
January 2025
Department of Family Medicine, Jagiellonian University Medical College, Kraków, 31-061, Poland.
Background: The COVID-19 pandemic has caused psychological distress to the population and healthcare workers. Physicians' well-being is essential and contributes significantly to overall health. This study aimed to assess the strain on Polish general practitioners from the effects of the COVID-19 pandemic and to ascertain the potential predictors of their distress.
View Article and Find Full Text PDFNovel, standardized sample collection from the brain-nose interface.
Methods
January 2025
Noselab GmbH, Widenmayerstr. 27, 80538 Munich, Germany.
Background: Diagnostics for neurodegenerative diseases lack non-invasive approaches suitable for early-stage biochemical screening and routine examination of neuropathology. Biomarkers of neurodegenerative diseases pass through the brain-nose interface (BNI) and accumulate in nasal secretion. Sample collection from the brain-nose interface presents a compelling prospect as basis for a non-invasive molecular diagnosis of neuropathologies.
View Article and Find Full Text PDFBarriers and Enablers in the Implementation of Physical Activity Improvement for Pregnant Women With Gestational Diabetes Mellitus: A Mixed-Methods Study.
J Adv Nurs
January 2025
Key Laboratory of Birth Defects and Related Diseases of Women and Children (Sichuan University), Ministry of Education, Chengdu, China.
Aim: To identify the barriers and enablers in the implementation of evidence-based physical activity (PA) programmes for the improvement of health outcomes among pregnant women with gestational diabetes mellitus (GDM), and to develop strategies for implementing this evidence in clinical practice.
Methods: A convergent mixed-methods study was conducted, integrating a descriptive qualitative research design with a cross-sectional survey. In-depth interview was used to collect the views and cognitions about physical activity from medical staff, leaders and pregnant women.
Want AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!