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Identification and characterization of novel polymorphisms in the basal promoter of the human transporter, MATE1.
Pharmacogenet Genomics
October 2009
Department of Pharmacology, Ewha Womans University, Seoul, Korea.
Objectives: Human multidrug and toxin extrusion member 1, MATE1 (SLC47A1), plays an important role in the renal and biliary excretion of endogenous and exogenous organic cations including many therapeutic drugs. In this study, we characterized the transcriptional effects of five polymorphic variants and six common haplotypes in the basal promoter region of MATE1 that were identified in 272 DNA samples from ethnically diverse US populations.
Methods: We measured luciferase activities of the six common promoter haplotypes of MATE1 using in-vitro and in-vivo reporter assays.
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