AI Article Synopsis
- The study examined how age affects the ultradian rhythms of total protein and albumin levels in rat lymph nodes under normal and chronic toxic oxidative stress conditions.
- The research found that these protein levels fluctuate in a consistent 20-60 minute rhythm, indicating a pattern (ultradian rhythm) influenced by both age and environmental stressors like exposure to sulfur-containing natural gas.
- Results suggest that as rats age, their lymph nodes have less adaptive resistance and their antioxidant systems become depleted, providing insights for potential treatments to mitigate the impacts of oxidative stress during aging.
Article Abstract
We studied the age-related features of the ultradian rhythms of levels of total protein and albumin in the lymph nodes under normal condition and chronic toxic oxidative stress condition using the chronobiological approach and the biochemical methods. During the experiment, we compared the rhythmic activity of levels of total protein and albumin in the rat lymph nodes in ontogenesis and during chronic exposure to sulfur-containing natural gas. The revealed fluctuations of the levels of total protein and albumin can be characterized as around-hourly (ultradian) rhythms, which period is approximately 20-40 to 60 minutes. The obtained experimental data indicate a decrease in the adaptive resistance of lymph node with age and the depletion of the antioxidant system of rats in aging. These results could have a practical value for the development of correction methods of negative effects of toxic oxidative stress in ontogenesis.
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