AI Article Synopsis
- The study investigates the role of serum acid-labile subunit (ALS) as a potential biomarker for diagnosing growth hormone deficiency (GHD) in children, alongside standard markers IGF-I and IGFBP-3.
- Ninety-one children undergoing GHD diagnosis were analyzed, revealing that IGF-I was the most significant predictor of GHD, with ALS contributing little to the diagnosis.
- The findings conclude that measuring ALS, whether alone or with other biomarkers, does not improve the detection of GHD compared to using IGF-I and IGFBP-3, which performed similarly in diagnostic accuracy.
Article Abstract
Background: The acid-labile subunit (ALS) is a crucial factor in the tertiary complex. IGF-I and IGFBP-3 are routinely measured during the diagnostic work-up for growth hormone deficiency (GHD). The aim of the study is to evaluate the relevance of serum ALS as an additional biomarker in the diagnosis of GHD.
Methods: Ninety-one children undergoing standard diagnostic work-up for GHD were included in this retrospective study. Inclusion criteria were evidence-based auxological cutoffs, IGF-I and IGFBP-3 <-2 SDS at first presentation, at least 1 growth hormone (GH) stimulation test, and IGF-I, IGFBP-3, and ALS measurements on the same day. Statistical analysis was performed by ROC as well as by odds ratio calculations.
Results: Forty-seven of 90 participants presented with peak GH values under the cutoff of 7 ng/mL. AUC from a model containing only IGF-I was 0.76 and 0.68 when using only ALS. A model containing IGF-I, IGFBP-3, and ALS (AUC = 0.77) did not improve the result compared to the combination of IGF-I/IGFBP-3 (0.77) or IGF-I/ALS (0.76). Furthermore, the variation in the outcome (GH peak
Conclusion: Determination of serum ALS alone or in combination with IGF-I and IGFBP-3 did not improve definition of biochemical GHD in a cohort of short children and adolescents with suspected growth disorder. However, performance of IGFBP-3 in this context was not statistically superior to ALS.
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| http://dx.doi.org/10.1159/000512336 | DOI Listing |
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