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<PubmedArticle><MedlineCitation Status="MEDLINE" Owner="NLM" IndexingMethod="Automated"><PMID Version="1">33341532</PMID><DateCompleted><Year>2021</Year><Month>10</Month><Day>25</Day></DateCompleted><DateRevised><Year>2021</Year><Month>10</Month><Day>25</Day></DateRevised><Article PubModel="Print-Electronic"><Journal><ISSN IssnType="Electronic">1872-7484</ISSN><JournalIssue CitedMedium="Internet"><Volume>230</Volume><PubDate><Year>2021</Year><Month>Jan</Month></PubDate></JournalIssue><Title>Autonomic neuroscience : basic &amp; clinical</Title><ISOAbbreviation>Auton Neurosci</ISOAbbreviation></Journal><ArticleTitle>Protective effects of quercetin-loaded microcapsules on the enteric nervous system of diabetic rats.</ArticleTitle><Pagination><StartPage>102759</StartPage><MedlinePgn>102759</MedlinePgn></Pagination><ELocationID EIdType="doi" ValidYN="Y">10.1016/j.autneu.2020.102759</ELocationID><ELocationID EIdType="pii" ValidYN="Y">S1566-0702(20)30193-4</ELocationID><Abstract><AbstractText>Quercetin-loaded microcapsules (QLM) promote controlled release and higher bioavailability of quercetin, an antioxidant and neuroprotective agent. We evaluated the antioxidant effect of QLM on enteric innervation and in the oxidative status of the ileum of diabetic rats. Wistar adult rats (Rattus norvegicus) were used in six groups containing normoglycemic (N), diabetic (D) and either normoglycemic or diabetic groups treated with QLM at a dose of 10&#xa0;mg/kg (NQ10 and DQ10, respectively) or 100&#xa0;mg/kg (NQ100 and DQ100, respectively). DQ10 e DQ100 did not prevent overall neuronal loss in the total and cholinergic populations. Nitrergic population showed differences regarding the treatments: DQ10 preserved neurons in the nitrergic population whilst DQ100 increased nitrergic loss. Evaluation of the redox status showed pro-oxidant effects in NQ100 by t-butyl-induced chemiluminescence analysis. We observed a reduction in the carbonylic content and an increase of low molecular weight antioxidants for DQ10 e DQ100. Therefore, QLM treatment at a dose of 10&#xa0;mg/kg acted positively on nitrergic neurons reducing oxidative damage induced by diabetes.</AbstractText><CopyrightInformation>Copyright &#xa9; 2020 Elsevier B.V. All rights reserved.</CopyrightInformation></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Sehaber-Sierakowski</LastName><ForeName>Camila Cavicchioli</ForeName><Initials>CC</Initials><AffiliationInfo><Affiliation>Laborat&#xf3;rio de Plasticidade Neural Ent&#xe9;rica, Universidade Estadual de Maring&#xe1;, Avenida Colombo, 5790 - Jd. Universit&#xe1;rio, Bloco O33, CEP: 87020-900 Maring&#xe1;, Paran&#xe1;, Brazil.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Vieira-Frez</LastName><ForeName>Fl&#xe1;via Cristina</ForeName><Initials>FC</Initials><AffiliationInfo><Affiliation>Laborat&#xf3;rio de Plasticidade Neural Ent&#xe9;rica, Universidade Estadual de Maring&#xe1;, Avenida Colombo, 5790 - Jd. Universit&#xe1;rio, Bloco O33, CEP: 87020-900 Maring&#xe1;, Paran&#xe1;, Brazil.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Hermes-Uliana</LastName><ForeName>Catchia</ForeName><Initials>C</Initials><AffiliationInfo><Affiliation>Universidade Federal do Mato Grosso do Sul, Campus de Tr&#xea;s Lagoas - CPTL. UNID. II: Avenida Ranulpho Marques Leal, 3484, CEP: 79613-000 Tr&#xea;s Lagoas, Mato Grosso do Sul, Brazil.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Martins</LastName><ForeName>Heber Amilcar</ForeName><Initials>HA</Initials><AffiliationInfo><Affiliation>Departmento de Medicina, Centro Universit&#xe1;rio de Maring&#xe1;, Avenida Guedner, 1610 - Jardim Aclima&#xe7;&#xe3;o, CEP: 87050-900, Maring&#xe1;, Paran&#xe1;, Brazil.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Bossolani</LastName><ForeName>Gleison Daion Piovezana</ForeName><Initials>GDP</Initials><AffiliationInfo><Affiliation>Laborat&#xf3;rio de Plasticidade Neural Ent&#xe9;rica, Universidade Estadual de Maring&#xe1;, Avenida Colombo, 5790 - Jd. Universit&#xe1;rio, Bloco O33, CEP: 87020-900 Maring&#xe1;, Paran&#xe1;, Brazil.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Lima</LastName><ForeName>Mariana Machado</ForeName><Initials>MM</Initials><AffiliationInfo><Affiliation>Laborat&#xf3;rio de Plasticidade Neural Ent&#xe9;rica, Universidade Estadual de Maring&#xe1;, Avenida Colombo, 5790 - Jd. Universit&#xe1;rio, Bloco O33, CEP: 87020-900 Maring&#xe1;, Paran&#xe1;, Brazil.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Blegniski</LastName><ForeName>Fernanda Paschoal</ForeName><Initials>FP</Initials><AffiliationInfo><Affiliation>Departamento de Patologia, Centro de Ci&#xea;ncias Biol&#xf3;gicas, Universidade Estadual de Londrina, Rodovia Celso Garcia Cid, Pr 445, Km 380, CEP: 86057-970 Londrina, Paran&#xe1;, Brazil.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Guarnier</LastName><ForeName>Fl&#xe1;via Alessandra</ForeName><Initials>FA</Initials><AffiliationInfo><Affiliation>Departamento de Patologia, Centro de Ci&#xea;ncias Biol&#xf3;gicas, Universidade Estadual de Londrina, Rodovia Celso Garcia Cid, Pr 445, Km 380, CEP: 86057-970 Londrina, Paran&#xe1;, Brazil.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Baracat</LastName><ForeName>Marcela Maria</ForeName><Initials>MM</Initials><AffiliationInfo><Affiliation>Departmento de Ci&#xea;ncias Farmac&#xea;uticas, Centro de Ci&#xea;ncias da Sa&#xfa;de, Hospital Universit&#xe1;rio, Universidade Estadual de Londrina, Avenida Robert Koch, 60, CEP: 86038-350 Londrina, Paran&#xe1;, Brazil.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Perles</LastName><ForeName>Juliana Vanessa Colombo Martins</ForeName><Initials>JVCM</Initials><AffiliationInfo><Affiliation>Laborat&#xf3;rio de Plasticidade Neural Ent&#xe9;rica, Universidade Estadual de Maring&#xe1;, Avenida Colombo, 5790 - Jd. Universit&#xe1;rio, Bloco O33, CEP: 87020-900 Maring&#xe1;, Paran&#xe1;, Brazil.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Zanoni</LastName><ForeName>Jacqueline Nelisis</ForeName><Initials>JN</Initials><AffiliationInfo><Affiliation>Laborat&#xf3;rio de Plasticidade Neural Ent&#xe9;rica, Universidade Estadual de Maring&#xe1;, Avenida Colombo, 5790 - Jd. Universit&#xe1;rio, Bloco O33, CEP: 87020-900 Maring&#xe1;, Paran&#xe1;, Brazil. Electronic address: jnzanoni@uem.br.</Affiliation></AffiliationInfo></Author></AuthorList><Language>eng</Language><PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType><PublicationType UI="D013485">Research Support, Non-U.S. Gov't</PublicationType></PublicationTypeList><ArticleDate DateType="Electronic"><Year>2020</Year><Month>12</Month><Day>04</Day></ArticleDate></Article><MedlineJournalInfo><Country>Netherlands</Country><MedlineTA>Auton Neurosci</MedlineTA><NlmUniqueID>100909359</NlmUniqueID><ISSNLinking>1566-0702</ISSNLinking></MedlineJournalInfo><ChemicalList><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D002214">Capsules</NameOfSubstance></Chemical><Chemical><RegistryNumber>9IKM0I5T1E</RegistryNumber><NameOfSubstance UI="D011794">Quercetin</NameOfSubstance></Chemical></ChemicalList><CitationSubset>IM</CitationSubset><MeshHeadingList><MeshHeading><DescriptorName UI="D000818" MajorTopicYN="N">Animals</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D002214" MajorTopicYN="N">Capsules</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D003921" MajorTopicYN="Y">Diabetes Mellitus, Experimental</DescriptorName><QualifierName UI="Q000188" MajorTopicYN="N">drug therapy</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D017615" MajorTopicYN="Y">Enteric Nervous System</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D026602" MajorTopicYN="Y">Nitrergic Neurons</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D018384" MajorTopicYN="N">Oxidative Stress</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D011794" MajorTopicYN="N">Quercetin</DescriptorName><QualifierName UI="Q000494" MajorTopicYN="N">pharmacology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D051381" MajorTopicYN="N">Rats</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D017208" MajorTopicYN="N">Rats, Wistar</DescriptorName></MeshHeading></MeshHeadingList><KeywordList Owner="NOTNLM"><Keyword MajorTopicYN="N">Antioxidant</Keyword><Keyword MajorTopicYN="N">Diabetes</Keyword><Keyword MajorTopicYN="N">Enteric nervous system</Keyword><Keyword MajorTopicYN="N">Oxidative stress</Keyword><Keyword MajorTopicYN="N">Quercetin</Keyword></KeywordList></MedlineCitation><PubmedData><History><PubMedPubDate PubStatus="received"><Year>2020</Year><Month>9</Month><Day>23</Day></PubMedPubDate><PubMedPubDate PubStatus="revised"><Year>2020</Year><Month>11</Month><Day>27</Day></PubMedPubDate><PubMedPubDate PubStatus="accepted"><Year>2020</Year><Month>12</Month><Day>2</Day></PubMedPubDate><PubMedPubDate PubStatus="pubmed"><Year>2020</Year><Month>12</Month><Day>21</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="medline"><Year>2021</Year><Month>10</Month><Day>26</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="entrez"><Year>2020</Year><Month>12</Month><Day>20</Day><Hour>20</Hour><Minute>26</Minute></PubMedPubDate></History><PublicationStatus>ppublish</PublicationStatus><ArticleIdList><ArticleId IdType="pubmed">33341532</ArticleId><ArticleId IdType="doi">10.1016/j.autneu.2020.102759</ArticleId><ArticleId IdType="pii">S1566-0702(20)30193-4</ArticleId></ArticleIdList></PubmedData></PubmedArticle></PubmedArticleSet>