AI Article Synopsis
Article Abstract
New Psychoactive Substances (NPS) are quickly developing to evade legislation, posing unprecedented challenges to public health and law enforcement authorities around the world. The aim of this work was to develop and validate a simple and reliable non-target gas chromatography/mass spectrometry (GC/MS) analytical method based on linear retention indexes for the expeditious identification of NPS without the need of analytical standards. The method was optimized and validated for 22 different drugs covering ten categories: phenethylamines (amphetamine, MDMA, methamphetamine, 25CNBOMe, 2-FA, 5-MAPB), "classic" drugs (cocaine, ephedrine, THC, heroine), synthetic cannabinoids (JWH-081, AM-2201, JWH-210, MAM-2201), piperazines (o-CPP, p-CPP), tryptamines (5-MeO-MiPT), synthetic cathinones (N-ethylpentylone), synthetic opioids (U-47700), aminoindanes (5-IAI), plant-based substances (Salvinorin-A) and "other" (methiopropamine). Three figures of merit (Selectivity, Precision and Robustness) were evaluated with retention index confidence intervals ranging from 0.5 to 20.6 i.u. and relative standard deviations in the range of 0.003% to 0.027% (repeatability) and 0.02% to 0.29% (intermediate precision). A general equation for estimating linear retention index variation as a function of retention time tolerance has been derived. This result in combination with a 2 fractional factorial design allowed to conclude column polarity to be only statistically relevant factor as compared to gas flow, split ratio, injection temperature, temperature program offset and column brand.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1016/j.chroma.2020.461783 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Biomimetic biomass-based composite carbon aerogels with excellent mechanical performance for energy storage and pressure sensing in extreme environments.
J Colloid Interface Sci
December 2024
Liaoning Province Key Laboratory of Pulp and Papermaking Engineering, Liaoning Key Lab of Lignocellulose Chemistry and BioMaterials, Liaoning Collaborative Innovation Center for Lignocellulosic Biorefinery, Dalian Polytechnic University, Dalian, Liaoning Province, 116034, China; Shandong Tonye Photoresist Material Technology CO., LTD, Weifang, 261206, China. Electronic address:
Article Synopsis
- The research addresses the low mechanical properties of biomass-based carbon aerogels, which limit their use in pressure sensing and energy storage for wearable tech and electronic skin.* -
- A new supramolecular assembly structure inspired by natural wood was developed, utilizing bacterial cellulose and lignin, enhanced with graphene oxide for better performance.* -
- The resulting carbon aerogels show remarkable features such as supercompressibility, high elasticity, stable sensor response, and impressive energy storage capabilities, making them ideal for wearable applications, even in extreme conditions.*
Development and validation of a liquid chromatography-tandem mass spectrometry (LC-MS/MS) assay for the quantification of oximes in KIKO mouse plasma.
J Chromatogr B Analyt Technol Biomed Life Sci
December 2024
United States Army Medical Research Institute of Chemical Defense, 8350 Ricketts Point Road, Aberdeen Proving Ground, MD 21010, USA. Electronic address:
Chemical warfare nerve agents (CWNAs) are potent and irreversible inhibitors of acetylcholinesterase (AChE). Oxime reactivators are an important part of the standard treatment for CWNA exposure as they can reactivate inhibited AChE. Evaluating the oxime candidates of interest in biological samples requires analytical detection methods and oxime reactivators as a class of compounds have historically been notoriously difficult to isolate, detect and analyze in an analytical laboratory, and there are currently no sensitive or robust analytical detection methods in the literature.
View Article and Find Full Text PDFRapid water drainage on human eyelashes of a hydrophobic fiber array.
Sci Adv
December 2024
CAS Key Laboratory of Bio-inspired Materials and Interfacial Science, Technical Institute of Physics and Chemistry, Chinese Academy of Sciences, Beijing 100190, China.
Numerous organisms exploit asymmetrical capillary forces generated by unique fiber or asymmetrical tapered structures to rapidly eliminate undesired liquid for survival in moist or rainy habitats. Human eyelashes, the primary protector of eyes, use a yet-to-be-fully-understood mechanism to efficiently transfer incoming liquid for vision safeguarding. Here, we elucidate that human eyelashes featuring a hydrophobic curved flexible fiber array with surface micro-ratchet and macro-curvature approximating the is adept at directionally and rapidly expelling incoming liquid to maintain clear vision.
View Article and Find Full Text PDFHigh-performance liquid chromatography method for measuring Captopril: an empirical study on hydrogel film permeability test.
Daru
December 2024
Faculty of Pharmacy, Universitas Indonesia, Depok, Indonesia.
Background: High-performance liquid chromatography (HPLC) has emerged as a highly sensitive and versatile analytical technique for quantifying antihypertensive drugs, such as Captopril (CAP). This study focused on the optimization and validation of an HPLC method for quantifying CAP in an in vitro hydrogel permeability test.
Objectives: The main objective of this study was to develop and validate an HPLC method for quantifying CAP in an in vitro hydrogel permeability test.
Adaptive significance of age- and light-related variation in needle structure, photochemistry, and pigments in evergreen coniferous trees.
Photosynth Res
February 2025
Faculty of Forestry and Wood Technology, Poznan University of Life Sciences, Wojska Polskiego 71E, 60-625, Poznan, Poland.
Evergreen conifers thrive in challenging environments by maintaining multiple sets of needles, optimizing photosynthesis even under harsh conditions. This study aimed to investigate the relationships between needle structure, photosynthetic parameters, and age along the light gradient in the crowns of Abies alba, Taxus baccata, and Picea abies. We hypothesized that: (1) Needle structure, photochemical parameters, and photosynthetic pigment content correlate with needle age and light levels in tree crowns.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!