Takashi Sugimura, M.D., Honorary President of the National Cancer Center in Tokyo, and former President of The Japan Academy, is regarded by many as a pre-eminent contributor to the field of environmental genotoxicology. His pioneering spirit led to many key discoveries over a long and distinguished scientific career, including the first preclinical models for gastric cancer, identification of novel mutagens from cooked food, and the development of fundamental concepts in environmental chemical carcinogenesis. With his passing on September 6, 2020, many will reflect on the loss of an astute and engaging "Scientific Giant," who with warmth and good humor maintained lasting friendships both at home and abroad, beyond his many important scientific contributions.
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The linac-base neutron source "iBNCT" developed by the Tsukuba team has begun to generate a large intensity of neutrons. To confirm the applicability of the device to BNCT, several characteristic measurements have been implemented. In a water phantom experiment, when the accelerator was operated with an average current of 1.
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Proc Natl Acad Sci U S A
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Graduate School of Life Science, University of Hyogo, Ako, 678-1297 Hyogo, Japan;
Cytochrome oxidase (CcO), a membrane enzyme in the respiratory chain, catalyzes oxygen reduction by coupling electron and proton transfer through the enzyme with a proton pump across the membrane. In all crystals reported to date, bovine CcO exists as a dimer with the same intermonomer contacts, whereas CcOs and related enzymes from prokaryotes exist as monomers. Recent structural analyses of the mitochondrial respiratory supercomplex revealed that CcO monomer associates with complex I and complex III, indicating that the monomeric state is functionally important.
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Graduate School of Material Science, University of Hyogo, 3-2-1 Kohto, Kamigori, Hyogo, 678-1297, Japan.
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Biosci Biotechnol Biochem
December 2017
c Department of Material Science, Graduate School of Material Science , University of Hyogo, Kamigori , Japan.
Article Synopsis
- A new electron-accepting form of vitamin K, specifically 5'-hydroxyphylloquinone (1), has been identified in photosystem I of certain oxygenic photosynthetic microorganisms.
- The structure of 5'-hydroxyphylloquinone was confirmed through a method known as stereo-uncontrolled synthesis.
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