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Incidence of symptomatic venous thromboembolism following hospitalization for coronavirus disease 2019: Prospective results from a multi-center study. | LitMetric

AI Article Synopsis

  • - The study investigated the incidence of venous thromboembolism (VTE) in COVID-19 patients after they were discharged from the hospital, tracking 1,529 patients for at least 45 days through follow-up calls.
  • - Out of those, 228 patients reported potential VTE symptoms, but only one was diagnosed with symptomatic pulmonary embolism (PE), leading to a low rate of symptomatic VTE of 0.2% within the study period.
  • - The findings suggest that routine use of extended thromboprophylaxis after hospitalization for COVID-19 may not be beneficial, indicating that further randomized trials are needed to clarify this issue.

Article Abstract

Background: Thrombosis and pulmonary embolism appear to be major causes of mortality in hospitalized coronavirus disease 2019 (COVID-19) patients. However, few studies have focused on the incidence of venous thromboembolism (VTE) after hospitalization for COVID-19.

Methods: In this multi-center study, we followed 1529 COVID-19 patients for at least 45 days after hospital discharge, who underwent routine telephone follow-up. In case of signs or symptoms of pulmonary embolism (PE) or deep vein thrombosis (DVT), they were invited for an in-hospital visit with a pulmonologist. The primary outcome was symptomatic VTE within 45 days of hospital discharge.

Results: Of 1529 COVID-19 patients discharged from hospital, a total of 228 (14.9%) reported potential signs or symptoms of PE or DVT and were seen for an in-hospital visit. Of these, 13 and 12 received Doppler ultrasounds or pulmonary CT angiography, respectively, of whom only one patient was diagnosed with symptomatic PE. Of 51 (3.3%) patients who died after discharge, two deaths were attributed to VTE corresponding to a 45-day cumulative rate of symptomatic VTE of 0.2% (95%CI 0.1%-0.6%; n = 3). There was no evidence of acute respiratory distress syndrome (ARDS) in these patients. Other deaths after hospital discharge included myocardial infarction (n = 13), heart failure (n = 9), and stroke (n = 9).

Conclusions: We did not observe a high rate of symptomatic VTE in COVID-19 patients after hospital discharge. Routine extended thromboprophylaxis after hospitalization for COVID-19 may not have a net clinical benefit. Randomized trials may be warranted.

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Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7836837PMC
http://dx.doi.org/10.1016/j.thromres.2020.12.001DOI Listing

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