AI Article Synopsis
- The National Toxicology Program is assessing the toxicity of bisphenol AF (BPAF) due to its structural similarity to bisphenol A and insufficient safety data.
- The study measured free (unconjugated) and total (free plus conjugated) levels of BPAF in Hsd:Sprague Dawley rats after dietary exposure during key developmental periods, revealing that levels in mothers increase with dosage and that BPAF metabolizes significantly in adults.
- Findings indicate significant transfer of BPAF from mothers to offspring, suggesting that rodent studies may help predict potential risks for human exposure due to similarities in enzyme development.
Article Abstract
Due to structural similarity to bisphenol A and lack of safety data, the National Toxicology Program (NTP) is evaluating the potential toxicity of bisphenol AF (BPAF) in rodent models. The current investigation reports the internal exposure data for free (unconjugated BPAF) and total (free and conjugated forms) BPAF during critical stages of development following perinatal dietary exposure in Hsd:Sprague Dawley®SD® rats to 0 (vehicle control), 338, 1125, and 3750 ppm BPAF from gestation day (GD) 6 to postnatal day (PND) 28. Free and total BPAF concentrations in maternal plasma at GD 18, PND 4, and PND 28 increased with the exposure concentration; free BPAF concentrations were ≤ 1.61% those of total BPAF demonstrating extensive first pass metabolism of BPAF following dietary exposure in adults. Free and total BPAF were quantified in GD 18 fetuses and PND 4 pups with free concentrations 11.7-53.4% that of corresponding total concentrations. In addition, free concentrations were higher (130-571%) and total concentrations were lower (1.71-7.23%) than corresponding concentrations in dams, demonstrating either preferential transfer of free BPAF and/or inability of fetuses and pups to conjugate BPAF. Free and total concentrations in PND 28 pups were similar to maternal concentrations demonstrating direct exposure of pups via feed and that conjugating enzymes are developed in PND 28 pups. In conclusion, these data demonstrate considerable gestational and lactational transfer of parent aglycone from the mother to offspring. Since the ontogeny of conjugating enzymes in humans is similar to that of rodents, the data from rodent BPAF studies may be useful in predicting human risk from exposure to BPAF.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7821698 | PMC |
| http://dx.doi.org/10.1016/j.taap.2020.115369 | DOI Listing |
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Article Synopsis
- * High BPAF exposure significantly lowered survival rates, changed sex ratios, and improved body growth but impaired swimming ability while causing major health issues like disrupted ovarian development and liver inflammation.
- * The study found that BPAF exposure affected key gene expressions related to the nervous and reproductive systems, alongside altering gut microbiota, indicating severe neurotoxic and reproductive risks from this environmental pollutant.
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