AI Article Synopsis
- Oral administration of pilocarpine was found to increase salivary flow in sicca (dry mouth) patients, but its impact on the structure and blood flow of salivary glands and periodontal health was unclear.
- In a study involving sicca patients, echostructural and vascular assessments of salivary glands were conducted before and after treating with pilocarpine, alongside dental evaluations for changes in salivary flow and periodontal health.
- Although pilocarpine successfully increased stimulated and unstimulated salivary flow after three months, no significant changes were observed in the structural or vascular parameters of salivary glands, nor in periodontal health.
Article Abstract
Introduction: Oral administration of pilocarpine enhances salivary flow in sicca patients but its effect upstream on ultrasound (US) of salivary glands (SG) and downstream on periodontium remain unknown.
Methods: Sicca patients were prospectively included. Echostructural and vascularization of SG were assessed using B mode and pulsed Doppler (USPD). Vascularization of SG was measured using resistive index (RI) before and after stimulation by lemon juice. Echostructure (measure of glandular length in cm, evaluation of parotid and submandibular glands parenchymal abnormalities) was assessed at baseline (M0) and after 3 months (M3) of treatment with pilocarpine. A dental consultation was performed at M0 and M3 to evaluate changes in unstimulated salivary flow (USSF), stimulated salivary flow (SSF), and periodontal parameters such as modified gingival index (Lobene), plaque index (Silness), bleeding index, pocket depth, and pH.
Results: Nineteen patients were included but only 11 received pilocarpine treatment for 3 months, as six stopped pilocarpine due to side effects and two were excluded for other causes. Among the 11 patients who completed the 3-month follow-up, five had primary Sjögren's syndrome according to the American-European's classification criteria. As expected, statistical differences were found concerning SSF (p = 0.018) and USSF (p = 0.027) between M0 and M3 while no statistical change in both SG echostructure and vascularization or periodontal evaluation was shown.
Conclusions: Pilocarpine improved SSF and USSF measurements in sicca syndrome but no ultrasonography of major salivary glands (SGUS) structural and vascular changes were detected as well as periodontal evaluation.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7990995 | PMC |
| http://dx.doi.org/10.1007/s40744-020-00263-y | DOI Listing |
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