AI Article Synopsis
- * Mesenchymal stem cells (MSCs) can help treat atherosclerosis, and this study identifies the role of microRNA-145 (miR-145) in this condition through advanced sequencing and analysis.
- * The research shows that exosomes rich in miR-145 from MSCs can effectively target and treat endothelial cells, potentially reducing plaque buildup and preventing atherosclerosis.
Article Abstract
Atherosclerosis is a chronic inflammatory disease associated with the development of plaques that can be converted into an acute clinical event by thrombosis or plaque rupture. Mesenchymal stem cells (MSCs) exhibit therapeutic effects for the treatment of various diseases, including atherosclerosis. In this study, we show that microRNA-145 (miR-145) is associated with atherosclerosis by microRNA sequencing and bioinformatics analysis. MSC-derived miR-145-rich exosomes could efficiently deliver miR-145 from MSCs to human umbilical vein endothelial cells (HUVECs). Treatment of miR-145-rich exosomes could downregulate JAM-A, inhibit migration , and reduce atherosclerotic plaque . Our study suggests that MSC-derived miR-145-rich exosomes have great potential for atherosclerosis prevention.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7732974 | PMC |
| http://dx.doi.org/10.1016/j.omtn.2020.10.037 | DOI Listing |
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