Recent progress in reducing malaria cases and ensuing deaths is threatened by factors like mutations that induce resistance to artemisinin derivatives. Multiple drugs are currently in clinical trials for malaria treatment, including some with novel mechanisms of action. One of these, MMV390048, is a plasmodial kinase inhibitor. This review lists the recently developed molecules which target plasmodial kinases. A systematic review of the literature was performed using CAPLUS and MEDLINE databases from 2005 to 2020. It covers a total of 60 articles and describes about one hundred compounds targeting 22 plasmodial kinases. This work highlights the strong potential of compounds targeting plasmodial kinases for future drug therapies. However, the majority of the kinome remains to be explored.
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| http://dx.doi.org/10.3390/molecules25245949 | DOI Listing |
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Article Synopsis
- The malaria parasite can alter its transcriptome to resist the effects of drugs, particularly affecting multigene families.
- CDPK family protein kinases in Plasmodium falciparum are crucial for its development and are potential targets for anti-malarial drugs.
- By using a chemical genetics approach to study a mutant parasite with a modified cdpk1 gene, researchers aim to discover compensatory mechanisms that could be targeted to combat drug resistance.
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