AI Article Synopsis
- Cancer immunotherapy has become a key strategy for treating cancer, but it faces challenges like poor targeting and side effects that limit its clinical effectiveness.
- Researchers are exploring new methods, particularly nano-immunotherapy, which utilizes nanoparticles to enhance the delivery and effectiveness of immunotherapeutic agents while minimizing side effects.
- The review discusses the role of nanoparticles as carriers for these agents and how they can also function as direct immunomodulators to improve antitumor activity and patient survival rates.
Article Abstract
In the last few decades, cancer immunotherapy becomes an important tactic for cancer treatment. However, some immunotherapy shows certain limitations including poor therapeutic targeting and unwanted side effects that hinder its use in clinics. Recently, several researchers are exploring an alternative methodology to overcome the above limitations. One of the emerging tracks in this field area is nano-immunotherapy which has gone through rapid progress and revealed considerable potentials to solve limitations related to immunotherapy. Targeted and stimuli-sensitive biocompatible nanoparticles (NPs) can be synthesized to deliver immunotherapeutic agents in their native conformations to the site of interest to enhance their antitumor activity and to enhance the survival rate of cancer patients. In this review, we have discussed cancer immunotherapy and the application of NPs in cancer immunotherapy, as a carrier of immunotherapeutic agents and as a direct immunomodulator.
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|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7765190 | PMC |
| http://dx.doi.org/10.3390/cancers12123773 | DOI Listing |
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