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Exogenous LEA proteins expression enhances cold tolerance in mammalian cells by reducing oxidative stress.
Sci Rep
January 2025
Department of Veterinary Medicine, University of Teramo, Via Renato Balzarini 1, 64100, Teramo, Italy.
Understanding the molecular mechanisms that confer cold resistance in mammalian cells might be relevant for advancing medical applications. This study aimed to exploit the protective function of Late Embryogenesis Abundant (LEA) proteins, known to provide resistance to low temperatures in extremophiles and plants, by their exogenous expression in mammalian cells, and compare their effects with the well characterized antioxidant, vitamin E.Remarkably, the expression of LEA proteins in mammalian cells exerted cold-protective effect similar to Vitamin E.
View Article and Find Full Text PDFThe interplay between retinoic acid binding proteins and retinoic acid degrading enzymes in modulating retinoic acid concentrations.
Curr Top Dev Biol
January 2025
Department of Pharmaceutics, School of Pharmacy, University of Washington.
The active metabolite of vitamin A, all-trans-retinoic acid (atRA), is critical for maintenance of many cellular processes. Although the enzymes that can synthesize and clear atRA in mammals have been identified, their tissue and cell-type specific roles are still not fully established. Based on the plasma protein binding, tissue distribution and lipophilicity of atRA, atRA partitions extensively to lipid membranes and other neutral lipids in cells.
View Article and Find Full Text PDFRunning Low: A Seasonal Analysis of Micronutrient Deficiencies on External-Load Measures in Elite Female Rugby League Players.
Int J Sports Physiol Perform
January 2025
Research Institute for Sport and Exercise (UCRISE), University of Canberra, Canberra, ACT, Australia.
Unlabelled: Iron and vitamin D are essential for physiological mechanisms underpinning physical capacities characterizing team-sport performance. Yet, the impact of iron deficiency on physical capacities beyond endurance is not clear.
Purpose: The purpose of this study was to assess variations in seasonal micronutrient concentrations and how iron deficiency impacts external-load measures in elite female rugby league players.
Direct factor Xa inhibitors versus low molecular weight heparins or vitamin K antagonists for prevention of venous thromboembolism in elective primary hip or knee replacement or hip fracture repair.
Cochrane Database Syst Rev
January 2025
Division of Pulmonary, Critical Care, Sleep, and Occupational Medicine, Indiana University School of Medicine, Indianapolis, USA.
Background: People undergoing major orthopaedic surgery are at increased risk of postoperative thromboembolic events. Low molecular weight heparins (LMWHs) are recommended for thromboprophylaxis in this population. New oral anticoagulants, including direct factor Xa inhibitors, are recommended as alternatives.
View Article and Find Full Text PDFA sulfonated and nitrated polyether ether ketone/polyvinyl chloride modified atmosphere packaging delays the deterioration of grapes.
J Sci Food Agric
January 2025
College of Food Science and Engineering, South China University of Technology, Guangzhou, China.
Background: Polyether ether ketone (PEEK) was modified by a sulfuric and nitric acid mixed system to improve the solubility of the material and the gas selective permeability of the film. SN1 and SN5, synthesized from mixed acid systems (with ratios of nitric acid and sulfuric acid of 1:1 and 1:5, respectively) were chosen because they had comparable nitro groups but differing sulfonyl groups. To investigate the impact of the type and content of sulfonated and nitrated polyether ether ketone (SNPEEK) on the structure and physicochemical properties of the films, SN1/polyvinyl chloride (PVC) and SN5/polyvinyl chloride films were made by adding varying amounts of SN1 and SN5 (0.
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