What is the role of andexanet alfa in the reversal of anticoagulant effects?

JAAPA

Jenna Hill Sewell is a pharmacy resident at the Gulf Coast Veterans Healthcare System in Biloxi, Miss. LaKeisha Williams is a clinical associate professor at Xavier University of Louisiana College of Pharmacy in New Orleans, La. Ellen McKnight is a community pharmacist at Walgreens Pharmacy in Memphis, Tenn. Anthony Nguyen is a clinical pharmacist at Ochsner Medical Center in New Orleans. Miroslav Sarac is an assistant professor at the Faculty of Pharmacy, Novi Sad, University Business Academy in Novi Sad, Serbia. The authors have disclosed no potential conflicts of interest, financial or otherwise.

Published: January 2021

Although using direct oral anticoagulants increases patient risk for hemorrhagic events, FDA-approved options for reversing anticoagulant effects are limited. This article discusses one of the more recent FDA-approved antidotes, andexanet alfa, and provides guidelines for its safe and effective use.

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http://dx.doi.org/10.1097/01.JAA.0000723956.47623.90DOI Listing

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