AI Article Synopsis
- SARS-CoV-2 causes a global pandemic and studying immune responses in recovered individuals revealed significant insights.
- Analysis of T cell responses from 41 individuals, taken at 1.3 and 6.1 months post-infection, showed that memory T cells are persistent and can quickly respond to the virus.
- Recovered patients exhibit long-lasting changes in their CD4 and CD8 T cell populations, including alterations in activation and exhaustion markers.
Article Abstract
Unlabelled: SARS-CoV-2 is responsible for an ongoing pandemic that affected millions of individuals around the globe. To gain further understanding of the immune response in recovered individuals we measured T cell responses in paired samples obtained an average of 1.3 and 6.1 months after infection from 41 individuals. The data indicate that recovered individuals show persistent polyfunctional SARS-CoV-2 antigen specific memory that could contribute to rapid recall responses. In addition, recovered individuals show enduring immune alterations in relative numbers of CD4 and CD8 T cells, expression of activation/exhaustion markers, and cell division.
Summary: We show that SARS-CoV-2 infection elicits broadly reactive and highly functional memory T cell responses that persist 6 months after infection. In addition, recovered individuals show enduring immune alterations in CD4 and CD8 T cells compartments.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7743071 | PMC |
| http://dx.doi.org/10.1101/2020.12.08.416636 | DOI Listing |
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