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Circular RNA profiling reveals abundant and diverse circRNAs of SARS-CoV-2, SARS-CoV and MERS-CoV origin. | LitMetric

AI Article Synopsis

  • Circular RNAs (circRNAs) are found in both hosts and viruses and have critical roles in autoimmune diseases and viral infections.* -
  • Research identified significant quantities of circRNAs from coronaviruses like SARS-CoV-2, showing they are more abundant and longer than those from host DNA genomes.* -
  • This study provides the first evidence of diverse circRNAs from coronaviruses, suggesting new insights into how circRNAs are produced from RNA viruses.*

Article Abstract

Unlabelled: Circular RNAs (circRNAs) encoded by DNA genomes have been identified across host and pathogen species as parts of the transcriptome. Accumulating evidences indicate that circRNAs play critical roles in autoimmune diseases and viral pathogenesis. Here we report that RNA viruses of the genus of , SARS-CoV-2, SARS-CoV and MERS-CoV, encode a novel type of circRNAs. Through circRNA analyses of publicly available coronavirus-infection related deep RNA-Sequencing data, we identified 351, 224 and 2,764 circRNAs derived from SARS-CoV-2, SARS-CoV and MERS-CoV, respectively, and characterized two major back-splice events shared by these viruses. Coronavirus-derived circRNAs are more abundant and longer compared to host genome-derived circRNAs. Using a systematic strategy to amplify and identify back-splice junction sequences, we experimentally identified over 100 viral circRNAs from SARS-CoV-2 infected Vero E6 cells. This collection of circRNAs provided the first line of evidence for the abundance and diversity of coronavirus-derived circRNAs and suggested possible mechanisms driving circRNA biogenesis from RNA genomes. Our findings highlight circRNAs as an important component of the coronavirus transcriptome.

Summary: We report for the first time that abundant and diverse circRNAs are generated by SARS-CoV-2, SARS-CoV and MERS-CoV and represent a novel type of circRNAs that differ from circRNAs encoded by DNA genomes.

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Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7743059PMC
http://dx.doi.org/10.1101/2020.12.07.415422DOI Listing

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