AI Article Synopsis
- The study aimed to evaluate the long-term effects of Gamma Knife radiosurgery (GKRS) on large or growing asymptomatic meningiomas in 59 patients, with a median age of 56 years and follow-up of around 67 months.
- Results showed that 59.3% of tumors shrank, 39% remained stable, and only 1.7% progressed, indicating a high tumor control rate over time.
- Complications included new neurological symptoms in 15.3% of patients and peritumoral edema (PTE) in 25.4%, with tumor size and maximum dose being significant risk factors for PTE.
Article Abstract
Objective: The aims of this study were to investigate the long-term outcomes of initial Gamma Knife radiosurgery (GKRS) for large (≥20 mm) or documented growth asymptomatic meningiomas.
Design And Methods: This was a single-center retrospective study. Fifty-nine patients with large (≥20 mm) or documented growth asymptomatic meningiomas undergoing initial GKRS were enrolled. The median age was 56 (range, 27-83) years. The median time of follow-up was 66.8 (range, 24.6-245.6) months, and the median tumor margin dose was 13.0 Gy (range, 11.6-22.0 Gy).
Results: Tumors shrunk in 35 patients (59.3%) and remained stable in 23 (39.0%). One patient (1.7%) experienced radiological progression at 54 months after GKRS. The PFS was 100%, 97%, and 97% at 3, 5, and 10 years, respectively. Nine patients (15.3%) occurred new neurological symptoms or signs at a median time of 8.1 (range, 3.0-81.6) months. The symptom PFS was 90% and 78% at 5 and 10 years, respectively. Fifteen patients (25.4%) occurred peritumoral edema (PTE) at a median time of 7.2 (range, 2.0-81.6) months. One patient underwent surgical resection for severe PTE. In univariate and multivariate analysis, Only tumor size (≥25 mm) and maximum dose (≥34 Gy) were significantly associated with PTE [hazard ratio (HR)= 3.461, 95% confidence interval (CI)=1.157-10.356, p=0.026 and HR=3.067, 95% CI=1.068-8.809, P=0.037, respectively].
Conclusions: In this study, initial GKRS can provide a high tumor control rate as well as an acceptable rate of complications in large or documented growth asymptomatic meningiomas. GKRS may be an alternative initial treatment for asymptomatic meningiomas.
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Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7732633 | PMC |
| http://dx.doi.org/10.3389/fonc.2020.598582 | DOI Listing |
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