AI Article Synopsis
- The case discusses a 1.5-year-old boy with severe Wiskott-Aldrich Syndrome who contracted SARS-CoV-2 five months post-gene therapy treatment.
- Before the infection, the boy had successful gene-corrected cell engraftment, which restored his WASP expression and improved his immune system.
- Upon infection, he produced high levels of specific antibodies against SARS-CoV-2 and experienced a mild illness with minimal inflammation, contrasting his pre-treatment condition.
Article Abstract
In this work we present the case of SARS-CoV-2 infection in a 1.5-year-old boy affected by severe Wiskott-Aldrich Syndrome with previous history of autoinflammatory disease, occurring 5 months after treatment with gene therapy. Before SARS-CoV-2 infection, the patient had obtained engraftment of gene corrected cells, resulting in WASP expression restoration and early immune reconstitution. The patient produced specific immunoglobulins to SARS-CoV-2 at high titer with neutralizing capacity and experienced a mild course of infection, with limited inflammatory complications, despite pre-gene therapy clinical phenotype.
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Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7732473 | PMC |
| http://dx.doi.org/10.3389/fimmu.2020.603428 | DOI Listing |
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