AI Article Synopsis
- TAFRO syndrome and POEMS syndrome are both lymphoproliferative disorders characterized by high levels of interleukin-6 and VEGF, but the exact causes are still not well understood.
- There are reported similarities in the lymph node pathology of TAFRO syndrome, Multicentric Castleman disease (MCD), and some cases of POEMS syndrome, but there's no clear consensus on how they are related.
- A case was identified that exhibited characteristics of both TAFRO and POEMS syndromes, suggesting it might be a subtype of idiopathic MCD, which could help clarify the understanding of these disorders.
Article Abstract
TAFRO syndrome and POEMS syndrome are lymphoproliferative disorders with elevated interleukin-6 and vascular endothelial growth factor (VEGF) levels; however, their underlying pathogenic mechanisms remain unclear. Similarities have been reported in the pathological findings of the lymph nodes of TAFRO syndrome, Multicentric Castleman disease (MCD), and some cases of POEMS syndrome. However, there is no consensus on the relationship among them. We encountered a case of lymphoproliferative disorder that presented with manifestations of both TAFRO syndrome and POEMS syndrome. This case may be a subtype of idiopathic MCD and will be very important for establishing the disease concept of TAFRO syndrome and POEMS syndrome.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8188039 | PMC |
| http://dx.doi.org/10.2169/internalmedicine.5860-20 | DOI Listing |
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