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TXNIP Regulates Natural Killer Cell-Mediated Innate Immunity by Inhibiting IFN-γ Production during Bacterial Infection. | LitMetric

AI Article Synopsis

  • The study emphasizes the role of NK cell-derived interferon-γ (IFN-γ) in enhancing the function of innate immune cells to combat infections.
  • It identifies thioredoxin-interacting protein (TXNIP) as a key inhibitor of IFN-γ production in NK cells during bacterial infections by interfering with TAK1 activation.
  • The findings indicate that TXNIP negatively influences NK cell-mediated activation of macrophages, thereby impacting the host's defense against bacteria.

Article Abstract

The function of natural killer (NK) cell-derived interferon-γ (IFN-γ) expands to remove pathogens by increasing the ability of innate immune cells. Here, we identified the critical role of thioredoxin-interacting protein (TXNIP) in the production of IFN-γ in NK cells during bacterial infection. TXNIP inhibited the production of IFN-γ and the activation of transforming growth factor β-activated kinase 1 (TAK1) activity in primary mouse and human NK cells. TXNIP directly interacted with TAK1 and inhibited TAK1 activity by interfering with the complex formation between TAK1 and TAK1 binding protein 1 (TAB1). (KO) NK cells enhanced the activation of macrophages by inducing IFN-γ production during Pam3CSK4 stimulation or Staphylococcus aureus () infection and contributed to expedite the bacterial clearance. Our findings suggest that NK cell-derived IFN-γ is critical for host defense and that TXNIP plays an important role as an inhibitor of NK cell-mediated macrophage activation by inhibiting the production of IFN-γ during bacterial infection.

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Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7765025PMC
http://dx.doi.org/10.3390/ijms21249499DOI Listing

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