The environment has direct and indirect effects on mental health. Previous studies acknowledge that the poor design of communities and social environments leads to increased psychological distress, but methodological issues make it difficult to draw clear conclusions. Recent public health, leisure and recreation studies have tried to determine the relationship between recreation opportunities and mental health. However, previous studies have heavily focused on individual contexts rather than national or regional levels; this is a major limitation. It is difficult to reflect the characteristics of community environments effectively with such limited studies, because social environments and infrastructure should be analyzed using a spatial perspective that goes beyond an individual's behavioral patterns. Other limitations include lack of socioeconomic context and appropriate data to represent the characteristics of a local community and its environment. To date, very few studies have tested the spatial relationships between mental health and recreation opportunities on a national level, while controlling for a variety of competing explanations (e.g., the social determinants of mental health). To address these gaps, this study used multi-level spatial data combined with various sources to: (1) identify variables that contribute to spatial disparities of mental health; (2) examine how selected variables influence spatial mental health disparities using a generalized linear model (GLM); (3) specify the spatial variation of the relationships between recreation opportunities and mental health in the continental U.S. using geographically weighted regression (GWR). The findings suggest that multiple factors associated with poor mental health days, particularly walkable access to local parks, showed the strongest explanatory power in both the GLM and GWR models. In addition, negative relationships were found with educational attainment, racial/ethnic dynamics, and lower levels of urbanization, while positive relationships were found with poverty rate and unemployment in the GLM. Finally, the GWR model detected differences in the strength and direction of associations for 3109 counties. These results may address the gaps in previous studies that focused on individual-level scales and did not include a spatial context.
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http://dx.doi.org/10.3390/ijerph17249338 | DOI Listing |
Front Biosci (Landmark Ed)
January 2025
Division of Molecular Psychiatry, Center of Mental Health, University of Hospital Würzburg, 97080 Würzburg, Germany.
Background: The inheritance of the short allele, encoding the serotonin transporter (SERT) in humans, increases susceptibility to neuropsychiatric and metabolic disorders, with aging and female sex further exacerbating these conditions. Both central and peripheral mechanisms of the compromised serotonin (5-HT) system play crucial roles in this context. Previous studies on SERT-deficient (Sert) mice, which model human SERT deficiency, have demonstrated emotional and metabolic disturbances, exacerbated by exposure to a high-fat Western diet (WD).
View Article and Find Full Text PDFFront Biosci (Landmark Ed)
January 2025
The Key Laboratory of Model Animals and Stem Cell Biology in Hunan Province, Hunan Normal University Health Science Center, 410013 Changsha, Hunan, China.
Background: α thalassemia/mental retardation syndrome X-linked (ATRX) serves as a part of the sucrose nonfermenting 2 (SNF2) chromatin-remodeling complex. In interphase, ATRX localizes to pericentromeric heterochromatin, contributing to DNA double-strand break repair, DNA replication, and telomere maintenance. During mitosis, most ATRX proteins are removed from chromosomal arms, leaving a pool near the centromere region in mammalian cells, which is critical for accurate chromosome congression and sister chromatid cohesion protection.
View Article and Find Full Text PDFEur Stroke J
January 2025
Department of Neurology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.
Background: We aimed to assess impairments on health-related quality of life, and mental health resulting from Retinal artery occlusion (RAO) with monocular visual field loss and posterior circulation ischemic stroke (PCIS) with full or partial hemianopia using patient-reported outcome measures (PROMs).
Methods: In a prospective study, consecutive patients with acute RAO on fundoscopy and PCIS on imaging were recruited during their surveillance on a stroke unit over a period of 15 months. Baseline characteristics were determined from medical records and interviews.
Subst Use Misuse
January 2025
Defense Personnel and Security Research Center, Peraton, Seaside, California, USA.
Background: This study investigated relationships between low-income adolescent drinkers' frequent alcohol use and five factors: social disorganization, social structural, social integration, mental health, and access to healthcare.
Objective: A sample of 1,256 low-income adolescent drinkers and caregivers were extracted from the Future of Families and Child Wellbeing Study.
Results: Logistic regression yielded results showing adolescent drinkers' weekly drinking to be associated positively with Hispanic adolescents, drinking peers, adolescents' depression/anxiety, and caregiver's daily drinking.
Nurs Leadersh (Tor Ont)
June 2025
Clinical Practice Leader Corporate Interprofessional Practice Lakeridge Health Durham Region, ON.
The integration of artificial intelligence (AI) into healthcare represents a paradigm shift with the potential to enhance patient care and streamline clinical operations. This commentary explores the Canadian perspective on key organizational considerations for nurse executives, emphasizing the critical role they play in fostering the establishment of AI governance structures and advancing the front-line adoption of AI in nursing practice. The discussion delves into five domains of consideration, analyzing recent developments and implications for nursing executives.
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