It is a new challenge for medical students and teachers to set up basic study of Medical Immunology fully online during the outbreak of coronavirus disease 2019 (COVID-19). To achieve the same educational quality with that of offline teaching, the online education design should be reconstructed according to the online cognitive rules of the students. During teaching progress, a cutting-edge research paper on COVID-19 was utilized as the main line for education design to accomplish the immunology teaching. We also combined multiple sources in auxiliary classroom and improved the interaction between the students and teachers through internet which might be the privilege of online teaching. These attempts achieved the curriculum standard requirements and the expected effect of education, which might provide future reference regarding the online or online-offline combined teaching model of Medical Immunology.

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