Eight new diterpenoids (-) with varied structures were isolated from the aerial parts of . Among them, xerophilsin A () was found to be an unusual meroditerpenoid representing a hybrid of an kauranoid and a long-chain aliphatic ester, xerophilsins B-D (-) are dimeric -kauranoids, while xerophilsins E-H (-) are new kauranoids. The structures of - were elucidated mainly through the analyses of their spectroscopic data. The absolute configurations of , , and were confirmed by single-crystal X-ray diffraction, and the configuration of C-16 in was established through quantum chemical calculation of NMR chemical shifts, as well as modeling of key interproton distances. Bioactivity evaluation of all isolated compounds revealed that , , and inhibited NO production in LPS-stimulated RAW264.7 cells.
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