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The Close Relationship between the Golgi Trafficking Machinery and Protein Glycosylation. | LitMetric

The Close Relationship between the Golgi Trafficking Machinery and Protein Glycosylation.

Cells

Istituto di Biologia e Patologia Molecolari del CNR, Dipartimento di Biologia e Biotecnologie, Sapienza Università di Roma, 00185 Roma, Italy.

Published: December 2020

AI Article Synopsis

  • * Altered glycosylation patterns are linked to various health issues, including genetic disorders and cancers.
  • * The review discusses the complex processes that manage vesicle trafficking in the Golgi apparatus and how mutations can impact glycan biosynthesis and contribute to diseases.

Article Abstract

Glycosylation is the most common post-translational modification of proteins; it mediates their correct folding and stability, as well as their transport through the secretory transport. Changes in and linked glycans have been associated with multiple pathological conditions including congenital disorders of glycosylation, inflammatory diseases and cancer. Glycoprotein glycosylation at the Golgi involves the coordinated action of hundreds of glycosyltransferases and glycosidases, which are maintained at the correct location through retrograde vesicle trafficking between Golgi cisternae. In this review, we describe the molecular machinery involved in vesicle trafficking and tethering at the Golgi apparatus and the effects of mutations in the context of glycan biosynthesis and human diseases.

Download full-text PDF

Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7764369PMC
http://dx.doi.org/10.3390/cells9122652DOI Listing

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