AI Article Synopsis
- Hepatocellular carcinoma (HCC) has high mortality and lacks effective treatments for advanced stages; circRNAs show promise as biomarkers and therapeutic targets in HCC.
- Recent research indicates that circPUM1 may act as an oncogene, promoting the growth and spread of HCC cells both in lab settings and in live models by affecting EMT-related protein expression.
- Our findings suggest that circPUM1 enhances HCC development by up-regulating the MAP3K2 protein through interaction with miR-1208, highlighting its potential as a therapeutic target for HCC.
Article Abstract
Hepatocellular carcinoma (HCC) is a common disease with a significant mortality, and there is no effective treatment for advanced patients. Growing evidence indicates that circRNAs are closely related to HCC progression, may be used as biomarkers and targets for the diagnosis and treatment of HCC. Recent researches have shown that circPUM1 may play an oncogene role in a variety of human cancers, but its role in HCC development has not been reported. Our study found that circPUM1 could promote the proliferation, migration and invasion of HCC cells in vitro. In addition, in vivo studies showed that circPUM1 could increase the development of HCC tumours and regulate the expression of EMT-related proteins. Furthermore, we demonstrated that circPUM1 could promote the development of HCC by up-regulating the expression of MAP3K2 via sponging miR-1208. Our study suggested that circPUM1 may be a potential therapeutic target for HCC.
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Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7810943 | PMC |
| http://dx.doi.org/10.1111/jcmm.15998 | DOI Listing |
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