AI Article Synopsis
- Serous cysto-adenoma (SCA) is a rare benign pancreatic tumor that can look like other serious pancreatic conditions, such as neuroendocrine tumors.
- In a case study, a 63-year-old man had a 7 cm pancreatic lesion; initial tests were inconclusive, but a 68Ga-DOTA-peptide PET scan indicated a potential neuroendocrine tumor.
- After surgery, the final diagnosis revealed it was actually a micro-cystic SCA, highlighting the need for careful assessment to avoid misdiagnosis and unnecessary treatment of such tumors.
Article Abstract
Background: Serous cysto-adenoma (SCA) is a rare benign neoplasm of the pancreas. SCA can mimic other pancreatic lesions, such as neuroendocrine tumours. 68Gallium-DOTA-peptide Positron Emission Tomography (PET) is able to image in vivo the over-expression of the somatostatin receptors, playing an important role for the identification of neuroendocrine neoplasms.
Case Presentation: We reported a case of 63-year-old man, with a solid lesion of 7 cm of diameter of the body-tail of the pancreas. Two fine-needle-aspirations (FNA) were inconclusive. A 68Ga-DOTA-peptide PET-CT revealed a pathological uptake of the pancreatic lesion. The diagnosis of a pancreatic neuroendocrine neoplasm was established and a laparoscopic distal splenopancreatectomy and cholecystectomy was performed. Final histopathological report revealed the presence of a micro-cystic SCA.
Conclusions: The current case firstly reports a pancreatic SCA showing increased radiopharmaceutical uptake at 68Ga-DOTA-peptide PET-CT images. This unexpected finding should be taken into account during the diagnostic algorithm of a pancreatic lesion, in order to minimize the risk of misdiagnosis and overtreatment of SCA.
Download full-text PDF |
Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7737276 | PMC |
| http://dx.doi.org/10.1186/s12893-020-01004-2 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Somatostatin Receptor Imaging in the Diagnosis and Management of Parathyroid Neuroendocrine Neoplasia.
Diagnostics (Basel)
December 2024
Almazov National Medical Research Centre, 2 Akkuratova Street, Saint Petersburg 197341, Russia.
Background: Parathyroid tumors are classified as parathyroid neuroendocrine neoplasia (NEN) by the IARC-WHO classification. These tumors can occur with NENs from other sites, which often require total-body [68Ga]-DOTA-peptides PET/CT. This study aimed to assess the utility of [68Ga]-DOTA-peptide PET/CT in imaging parathyroid NENs and to evaluate the underlying mechanisms.
View Article and Find Full Text PDF68Ga-DOTA-peptide PET/CT for radiotherapy planning and evaluating treatment response in the management of meningiomas.
J Pak Med Assoc
June 2023
Section of Neurosurgery, Department of Surgery, Aga Khan University Hospital, Karachi.
Meningiomas overexpress somatostatin receptors (SSTR). PET imaging with SSTR ligands such as 68Ga-DOTA-peptide has recently shown high diagnostic accuracy in identification of meningiomas due to lack of normal bone and brain activity. PET-derived parameters, especially gross tumour volume (GTV) delineation improves inter-observer variability and appears to be particularly promising for RT planning.
View Article and Find Full Text PDFGa-DOTATATE Radioisotope scan to detect neuroendocrine tumors; A Cross-Sectional Study.
Asia Ocean J Nucl Med Biol
January 2022
Chronic Respiratory Diseases Research Center, National research institute of tuberculosis and lung diseases, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
Objevtives: Neuroendocrine tumors are a heterogeneous group of neoplasms that arise from the peptide-producing cells of the neuroendocrine system. Different functional imaging methods have been suggested to diagnose NETs. There is still not enough evidence to recommend Ga-DOTATATE as a standard diagnostic tool in NETs.
View Article and Find Full Text PDFPancreatic serous cystoadenoma (CSA) showing increased tracer uptake at 68-GaDOTA-peptide Positron Emission Tomography (68Ga-DOTA-peptide PET-CT): a case report.
BMC Surg
December 2020
Pancreatic Surgery Unit, Humanitas Clinical and Research Center-IRCCS Rozzano, Via Alessandro Manzoni, 56, 20089, Rozzano, Milan, Italy.
Article Synopsis
- Serous cysto-adenoma (SCA) is a rare benign pancreatic tumor that can look like other serious pancreatic conditions, such as neuroendocrine tumors.
- In a case study, a 63-year-old man had a 7 cm pancreatic lesion; initial tests were inconclusive, but a 68Ga-DOTA-peptide PET scan indicated a potential neuroendocrine tumor.
- After surgery, the final diagnosis revealed it was actually a micro-cystic SCA, highlighting the need for careful assessment to avoid misdiagnosis and unnecessary treatment of such tumors.
The Neuroendocrine Neoplasms of the Digestive Tract: Diagnosis, Treatment and Nutrition.
Nutrients
May 2020
Department of Human Nutrition and Metabolomic, Pomeranian Medical University in Szczecin, Broniewskiego 24 str, 71-460 Szczecin, Poland.
Nuroendocrine neoplasms (NENs) are a group of rare neoplasms originating from dispersed neuroendocrine cells, mainly of the digestive and respiratory tract, showing characteristic histology and immunoprofile contributing to classification of NENs. Some NENs have the ability to produce biogenic amines and peptide hormones, which may be associated with clinical syndromes like, e.g.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!