Ten novel (, , , , , , , , , and ) furancarboxylic acids including four pairs of epimers (, ; , ; , ; , ), together with seven known analogues (, , , , , , and ), were isolated from the fermentation of the soil-derived fungus sp. sb62. Their structures were established on the basis of spectroscopic data analysis, and the absolute configurations were determined by time-dependent density functional theory electronic circular dichroism calculations, comparison of the specific optical rotation values, and modified Mosher's method. Compounds - represent the first class of natural furancarboxylic acids featuring a thiophene moiety. Compounds - showed antimicrobial inhibitory activities against , , and with MIC values ranging from 0.9 to 7.0 μg/mL, from 1.7 to 3.5 μg/mL, and from 3.3 to 7.0 μg/mL, respectively.
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http://dx.doi.org/10.1021/acs.jnatprod.0c00758 | DOI Listing |
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