Antimicrobial Furancarboxylic Acids from a sp.

J Nat Prod

Hubei Key Laboratory of Natural Medicinal Chemistry and Resource Evaluation, School of Pharmacy, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, People's Republic of China.

Published: December 2020

Ten novel (, , , , , , , , , and ) furancarboxylic acids including four pairs of epimers (, ; , ; , ; , ), together with seven known analogues (, , , , , , and ), were isolated from the fermentation of the soil-derived fungus sp. sb62. Their structures were established on the basis of spectroscopic data analysis, and the absolute configurations were determined by time-dependent density functional theory electronic circular dichroism calculations, comparison of the specific optical rotation values, and modified Mosher's method. Compounds - represent the first class of natural furancarboxylic acids featuring a thiophene moiety. Compounds - showed antimicrobial inhibitory activities against , , and with MIC values ranging from 0.9 to 7.0 μg/mL, from 1.7 to 3.5 μg/mL, and from 3.3 to 7.0 μg/mL, respectively.

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Source
http://dx.doi.org/10.1021/acs.jnatprod.0c00758DOI Listing

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