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Life-threatening dermatoses.
Clin Dermatol
December 2024
Department of Dermatology, Yale University School of Medicine, New Haven, CT. Electronic address:
While rare, life-threatening dermatoses encompass various inflammatory, infectious, vasculitic/vasculopathy, paraneoplastic, and neoplastic skin diseases. Complications include skin barrier dysfunction, secondary infection, and internal organ involvement. Skin signs may serve as a critical window into systemic disease.
View Article and Find Full Text PDFHarnessing the Anti-Inflammatory Effects of Perinatal Tissue Derived Therapies for the Treatment of Inflammatory Skin Diseases: A Comprehensive Review.
Stem Cell Rev Rep
November 2024
Laser Application in Medical Sciences Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
Article Synopsis
- Chronic inflammatory skin conditions like atopic dermatitis and psoriasis are challenging to treat with existing options, such as topical corticosteroids, which have limitations and side effects.
- Recent research highlights the potential of placental derivatives—from decidua, placental membrane, and umbilical cord—to effectively treat these conditions by reducing inflammation and promoting healing.
- The use of these derivatives may revolutionize care by providing benefits for not just psoriasis and atopic dermatitis, but also other skin diseases like vitiligo and pemphigus, potentially changing treatment methodologies and improving patient outcomes.
Constrictive bronchiolitis and paraneoplastic pemphigus caused by unicentric Castleman disease in a young woman: a case report.
Front Med (Lausanne)
October 2024
Department of Pulmonary and Critical Care Medicine, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China.
Article Synopsis
- Constrictive bronchiolitis is a rare, severe condition causing irreversible small airway obstruction, potentially linked to an autoimmune syndrome stemming from Castleman disease.
- A 20-year-old female suffered from progressive breathing difficulties and oral sores, leading to an investigation that revealed a pelvic mass diagnosed as Castleman disease.
- Despite surgery to remove the mass alleviating some symptoms, she eventually required a lung transplant to significantly improve her lung function, highlighting the need for timely and thorough medical intervention.
HDAC1-mediated regulation of KDM1A in pemphigus vulgaris: unlocking mechanisms on ERK pathway activation and cohesion loss.
Hum Mol Genet
December 2024
Department of Dermatology, The First Affiliated Hospital of Chongqing Medical University, No. 1 Youyi Road, Yuzhong District, Chongqing 400016, China.
Pemphigus vulgaris (PV) is an autoimmune skin disorder characterized by the loss of cell cohesion, with the histone deacetylase 1 (HDAC1) and lysine demethylase 1A (KDM1A) playing critical roles in its pathogenesis. This study aimed to elucidate the molecular mechanisms behind PV, focusing on the function of HDAC1 and KDM1A in disease onset and progression. Based on in vitro and in vivo PV models, we observed a significant increase in HDAC1 mRNA and protein levels in skin tissues of PV patients.
View Article and Find Full Text PDFParaneoplastic pemphigus with airway involvement.
Respir Med Case Rep
July 2024
Division of Pulmonary and Critical Care Medicine, David Geffen School of Medicine, University of California, Los Angeles, USA.
Article Synopsis
- A case of paraneoplastic pemphigus led to severe respiratory failure caused by bronchiolitis obliterans, which improved with aggressive treatment.
- The treatment regimen included high doses of corticosteroids, rituximab, niacinamide, and doxycycline.
- This report is significant as it is the first documented instance of paraneoplastic pemphigus affecting the airways, highlighting the effectiveness of niacinamide and doxycycline in the treatment.
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