New F-labeled nonvolatile aldehyde prosthetic groups derived from [ F]F-Py-TFP and spirocyclic iodonium (III)ylide precursors for late stage F-labeling were developed. These precursors were characterized, F-labeled, and compared in reactivity for oxime coupling. Oxime coupling was performed on an amino-oxy modified inhibited factor VII (FVIIai-ONH ) in low concentration to prove the applicability of the proposed method.
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