AI Article Synopsis
- The study investigates how SARS-CoV-2, the virus responsible for COVID-19, can infect cells in the central nervous system (CNS) by analyzing glioblastoma, a type of brain tumor.
- It was found that the ACE2 receptor, necessary for the virus to enter cells, is highly expressed in certain cell types associated with the CNS, such as endothelial cells and neural precursor cells.
- The researchers emphasize the importance of monitoring patients with neurological symptoms during COVID-19, particularly those with glioma, due to the identified susceptibility of these brain cells to virus invasion.
Article Abstract
Background: Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) caused the recent global COVID-19 outbreak, which led to a public health emergency. Entry of SARS-CoV-2 into human cells is dependent on the SARS-CoV receptor, angiotensin converting enzyme 2 (ACE2) receptor, and cathepsin. Cathepsin degrades the spike protein (S protein), which results in the entry of viral nucleic acid into the human host cell.
Methods: We explored the susceptibility of the central nervous system (CNS) to SARS-CoV-2 infection using single-cell transcriptome analysis of glioblastoma.
Results: The results showed that ACE2 expression is relatively high in endothelial cells (ECs), bone marrow mesenchymal stem cells (BMSCs), and neural precursor cells (NPCs). Cathepsin B (Cat B) and cathepsin (Cat L) were also strongly expressed in various cell clusters within the glioblastoma microenvironment. Immunofluorescence staining of glioma and normal brain tissue chips further confirmed that ACE2 expression co-localized with CD31, CD73, and nestin, which confirmed the susceptibility to SARS-CoV-2 of nervous system cells, including ECs, BMSCs, and NPCs, from clinical specimens.
Conclusions: These findings reveal the mechanism of SARS-CoV-2 neural invasion and suggest that special attention should be paid to SARS-CoV-2-infected patients with neural symptoms, especially those who suffered a glioma.
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|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7703438 | PMC |
| http://dx.doi.org/10.3389/fonc.2020.566599 | DOI Listing |
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