Interacting with YBX1 to Regulate Apoptosis and Autophagy via MET and Phosphor-AMPKa Signaling.

Long noncoding RNA (lncRNA) has been reported to be upregulated in lung cancer and related to poor patient survival. It can regulate cell proliferation and tumor growth in lung cancer as well as several other cancers. However, the underlying molecular mechanisms that are regulated by are unclear. In this study, we found that silencing can impair cell proliferation in 14 different genomic alterations of lung cancer cell lines. These alterations are , , , , and mutations. The cell apoptosis and autophagy were induced upon silencing in lung cancer cells. Mechanistically, can bind to the Y-box binding protein 1 (YBX1) protein, prevent it from proteasomal degradation, and increase its nuclear translocation. regulated MET expression via YBX1 at a transcriptional level. Induced cell autophagy by knockdown was mainly through increased phosphor-AMP-activated protein kinase (p-AMPK)a. Collectively, YBX1-MET/p-AMPKa signaling is critical to regulate cell proliferation, apoptosis, and autophagy, which may provide a potential clinically therapeutic target in lung cancer.