Type 2 diabetes mellitus (T2DM) is an increasingly common disorder characterized by chronic hyperglycemia and marked dyslipidemia. This study evaluates the effect of vitamin D supplementation alone and in combination with glimepiride in streptozotocin-induced T2DM in rats. A total of 30 Wistar albino rats of either sex weighing 150-200 g were included in the study. The effect of oral administration of vitamin D was evaluated in streptozotocin-induced T2DM in rats. Blood glucose, serum insulin, serum HbA1c, and serum vitamin D were evaluated. D treatment has significantly improved hyperglycemia, hyperinsulinemia, and insulin sensitivity compared with the non-treated diabetic rats. Oral administration of vitamin D in streptozotocin-induced T2DM reduced blood sugar levels, increased insulin levels (more prominently when administered along with glimepiride) and decreased HbA1c levels (p<0.005). Administration of vitamin D can improve hyperglycemia and hyperinsulinemia in streptozotocin-induced T2DM in rats. Thus, it could be considered as an add on therapy along with other antidiabetic drugs.
Download full-text PDF |
Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7726512 | PMC |
| http://dx.doi.org/10.26574/maedica.2020.15.3.327 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Anthocyanin-rich black wheat as a functional food for managing type 2 diabetes mellitus: a study on high fat diet-streptozotocin-induced diabetic rats.
Food Funct
December 2024
Department of Biochemistry, Panjab University, Chandigarh, India.
: Type 2 Diabetes Mellitus (T2DM) is associated with insulin resistance, hyperglycemia, and hyperlipidemia. Anthocyanins, which are natural antioxidants, have been reported to manage T2DM-related complications. However, the potential of anthocyanin-rich black wheat as a functional food for managing diabetes remains unexplored.
View Article and Find Full Text PDFProtective effects of ghrelin on pancreas in fructose diet and streptozotocin-induced diabetic rats.
J Mol Histol
December 2024
Department of Medical Biology, Cerrahpaşa Faculty of Medicine, Istanbul University-Cerrahpaşa, Istanbul, Türkiye.
Ghrelin, which is widely expressed in central and peripheral tissues, has several metabolic effects. It has been suggested that these effects may include anti-inflammatory, anti-oxidant, and anti-apoptotic effects. Therefore, we aimed to investigate the effects of ghrelin administered to diabetic rats on DNA repair and apoptosis mechanisms, and differences in oxidative stress (OS) and pancreatic hormone levels in the pancreas.
View Article and Find Full Text PDFHovenia dulcis (Guaizao) polysaccharide ameliorates hyperglycemia through multiple signaling pathways in rats with type 2 diabetes mellitus.
Int J Biol Macromol
December 2024
College of Food Science, Southwest University, 2 Tiansheng Road, Beibei, Chongqing 400715, PR China. Electronic address:
Type 2 diabetes mellitus (T2DM) poses a significant threat to human health, with its incidence and mortality rates increasing annually. This study investigated the hypoglycemic effects and underlying mechanisms of pure Hovenia dulcis (Guaizao) polysaccharide (HDPs-2A) in rats subjected to a high-fat and high-sugar diet combined with streptozotocin-induced T2DM. Oral administration of HDPs-2A resulted in significant increases in body weight and liver glycogen levels compared to untreated controls.
View Article and Find Full Text PDFSustainable Intervention: Grape Pomace Flour Ameliorates Fasting Glucose and Mitigates Streptozotocin-Induced Pancreatic Damage in a Type 2 Diabetes Animal Model.
Pharmaceuticals (Basel)
November 2024
Center for Research in Biosciences & Health Technologies (CBIOS), Universidade Lusófona, 1749-024 Lisboa, Portugal.
: Type 2 Diabetes Mellitus (T2DM) is characterized by hyperglycemia, increased risk of cardiovascular diseases, and oxidative imbalances. This study aimed to investigate the impact of dietary supplementations with 'Arinto' grape pomace flour (GPF) (WGPF) and 'Touriga Nacional' GPF (RGPF) in an animal model of T2DM. : T2DM was induced by a high-fat diet (HFD) for 28 days and a single dose of streptozotocin (STZ) (35 mg/kg) on the 21st day.
View Article and Find Full Text PDFAstragalus polysaccharide ameliorates diabetic retinopathy by inhibiting the SHH-Gli1-AQP1 signaling pathway in streptozotocin-induced type 2 diabetic rats.
Korean J Physiol Pharmacol
January 2025
Department of Clinical Pharmacy, Zhucheng People's Hospital, Zhucheng 262200, China.
This study aims to investigate the effects of astragalus polysaccharide (APS) on diabetic retinopathy through the SHH-Gli1-AQP1 pathway. The anti-type 2 diabetes mellitus (T2DM) targets of APS were identified through comprehensive searches of drug and disease-related databases. A protein-protein interaction network was then constructed, followed by GO and KEGG enrichment analyses.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!