Evolution of Diagnostic and Treatment Patterns of Cardiac Sarcoidosis.

Mo Med

Anna Grodzinsky, MD, MSc, Timothy J. Fendler, MD, Gregory Howell, MD, Sanjaya Gupta, MD, Stephanie Lawhorn, MD, MSMA member since 2014, Brett Sperry, MD, Siva Sagar Taduru, MD and Ibrahim M. Saeed, MD, are with the University of Missouri - Kansas City School of Medicine and Saint Luke's Mid-America Heart Institute Hospital in Kansas City, Missouri. Bhaskar Bhardwaj, MD, MSMA member since 2020, is with the University of Missouri - Columbia Department of Cardiovascular Disease, and Akshit Sharma, MD, is with the University of Kansas Medical Center Division of Cardiovascular Disease.

Published: August 2021

Cardiac sarcoidosis (CS) may impart substantial morbidity and mortality, and novel imaging modalities are now available to aid in early diagnosis of this clinically silent disease. A better understanding of the clinical experience with CS is important. Twenty-eight patients were diagnosed with the aid of multimodality imaging techniques and were treated by a multidisciplinary team. Demographics, symptomatology, imaging, and therapeutic interventions were compiled from our referral center. In patients with CS, nuclear and MR techniques were often the first studies performed. Echocardiographic findings differed widely. Immunosuppressive therapy and cardiac devices were frequently used. Importantly, isolated CS was not an infrequent finding.

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Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7721427PMC

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Article Synopsis
  • Sarcoidosis is a rare chronic disease with an unclear cause, making cardiac sarcoidosis (CS) diagnosis particularly challenging.
  • Current guidelines for diagnosing CS lack clinical validation, and while endomyocardial biopsy is specific, it is not very sensitive and has significant risks.
  • A case study of a 63-year-old man diagnosed with CS through endobronchial ultrasound transbronchial needle aspiration (EBUS TBNA) of normal lymph nodes suggests that EBUS TBNA could be a viable option for diagnosing CS in cases without clear pulmonary sarcoidosis evidence.
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Aims: The prognostic role of high-sensitivity cardiac troponin T (hs-cTnT) as a biomarker in patients with cardiac sarcoidosis (CS) has yet to be fully determined, especially when compared with B-type natriuretic peptide (BNP).

Methods And Results: In this post-hoc analysis of the ILLUMINATE-CS (ILLUstration of the Management and prognosIs of JapaNese pATiEnts with Cardiac Sarcoidosis), which is a multicentre retrospective observational study, we analysed 103 patients (62.2 ± 10.

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