Background There have been growing interests in the association between vitamin D and depression in recent years. Objective The objective of this study was to find the prevalence of low vitamin D level in the patients suffering from depressive episodes. The next objective was to determine whether there are any statistically significant differences between the mean vitamin D levels of different sociodemographic variables and also to find the sociodemographic variables predicting the vitamin D level. Method The patients diagnosed as depressive episodes were selected from the out-patient unit of Department of Psychiatry of Manipal Teaching Hospital, Pokhara. The proforma was used to collect the sociodemographic profile of the patient. The diagnosis of depressive episode was made according to the International Classification of Disease-10 Classification of Mental and Behavioural Disorders: Diagnostic Criteria for Research. The serum vitamin D level of less than 30 ng/ml was considered as low level in this study. Result The prevalence of low vitamin level was found in 81.8%. The mean difference of vitamin D level was statistically significant in gender and marital status of the patients. The low mean vitamin level was found in the socio-demographic variables like in age above 60 years, Newar caste, female gender, separated from the spouse patients and in the patients living in the urban area as compared to other group of patients. The gender of the patients predicted vitamin D level in the depressed patients. Conclusion There is high prevalence of low vitamin D level in the depressed patients. The correction of low vitamin D level would be helpful in the holistic management of patient with depressive episodes.
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Clin Rheumatol
January 2025
Department of Molecular Biology, Institute of Genomic Science and Medicine, Juárez Avenue 1822 Oriente, 27000, Torreón, Coahuila, México.
Vitamin D deficiency is a public health problem worldwide. Some studies have associated serum vitamin D deficiency with knee osteoarthritis. Additionally, some vitamin D receptor polymorphisms have been linked to knee osteoarthritis.
View Article and Find Full Text PDFNanotechnology
January 2025
Department of Biotechnology, Kalasalingam Academy of Research and Education (Deemed to be University), Anand Nagar, School of Bio, Chemical & Process Enginneering, Krishnankoil, Krishnan Kovil, Tamil Nadu, 626126, INDIA.
Significant progress has been made in cancer therapy with protein-based nanocarriers targeted directly to surface receptors for drug delivery. The nanocarriers are a potentially effective solution for the potential drawbacks of traditional chemotherapy, such as lack of specificity, side effects, and development resistance. Peptides as nanocarriers have been designed based on their biocompatible, biodegradable, and versatile functions to deliver therapeutic agents into cancer cells, reduce systemic toxicity, and maximize therapy efficacy through utilizing targeted ligands such as antibodies, amino acids, vitamins, and other small molecules onto protein-based nanocarriers and thus ensuring that drugs selectively accumulate in the cancer cells instead of healthy organs/drug release at a target site without effects on normal cells, which inherently caused less systemic toxicity/off-target effect.
View Article and Find Full Text PDFMagnes Res
January 2025
Department of neurosurgery, Hangzhou TCM Hospital Affiliated to Zhejiang Chinese Medical University, Hangzhou 310007, Zhejiang, China.
This study aimed to explore the association between serum vitamin D and/or dietary magnesium intake levels and severe hepatic steatosis. This cross-sectional study collected data from 2,874 individuals in the NHNAES database between 2017 and 2018. Variables were subjected to weighted univariate logistic regression analysis, and variables with p<0.
View Article and Find Full Text PDFACS Nano
January 2025
College of Pharmaceutical Sciences, Zhejiang University, 866 Yuhangtang Road, Hangzhou, Zhejiang 310058, P. R. China.
Atopic dermatitis (AD) is a recurrent and chronic inflammatory skin condition characterized by a high lifetime prevalence and significant impairment of patients' quality of life, primarily due to intense itching and discomfort. However, current pharmacological interventions provide only moderate efficacy and are frequently accompanied by adverse side effects. The immune-pathogenesis of AD involves dysregulation of the Th2 immune response and exacerbation of inflammation related to excessive reactive oxygen species (ROS).
View Article and Find Full Text PDFFront Nutr
January 2025
Chair of Epidemiology, University of Augsburg, Augsburg, Germany.
Objective: Monitoring dietary habits is crucial for identifying shortcomings and delineating countermeasures. About 20 years after the last population-based surveys in Bavaria and Germany, dietary habits were assessed to describe the intake distributions and compare these with recommendations at food and nutrient level.
Methods: The 3rd Bavarian Food Consumption Survey (BVS III) was designed as a diet survey representative of adults in Bavaria; from 2021 to 2023, repeated 24-h diet recalls were collected by telephone using the software GloboDiet©.
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