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Evaluating student understanding of pharmacodynamics core concepts.
Eur J Pharmacol
January 2025
Faculty of Pharmacy and Pharmaceutical Sciences, Monash University, Australia. Electronic address:
Pharmacodynamics is an essential subdiscipline of pharmacology that underpins safe and effective prescribing and therapeutic decision-making, as well as drug discovery and development. The exponential increase in the number of therapeutic drugs has prompted members of the pharmacology educator community to question existing pharmacology curricula focused on individual drugs and move toward a curriculum focused on conceptual understanding. A first step towards conceptual understanding is to establish what students currently know about pharmacodynamic core concepts.
View Article and Find Full Text PDFRural Surgery Experiences in General Surgery Residency Training-The Current State an ACGME Sponsored Survey of General Surgery Program Directors.
J Surg Educ
January 2025
ACMGE Surgery Residency Review Committee, Chicago, Illinois.
Objective: Nationwide there is a significant shortage of surgeons in rural communities, which has led to a growing interest in training more general surgeons specifically for entry into rural practice. Despite noble intentions, exactly how this training should be performed is unclear, and highly variable across programs. The Accreditation Council for Graduate Medical Education (ACGME) Surgery Residency Review Committee (RRC) sought to better understand the current state of rural focused training options in general surgery residencies.
View Article and Find Full Text PDFCAMSAP2 is required for bridging fiber assembly to ensure mitotic spindle assembly and chromosome segregation in human epithelial Caco-2 cells.
PLoS One
January 2025
Department of Life Science and Medical Bioscience, Laboratory of Cytoskeletal Logistics, Graduate School of Advanced Science and Engineering, Waseda University, Shinjuku, Tokyo, Japan.
In mammalian epithelial cells, cytoplasmic microtubules are mainly non-centrosomal, through the functions of the minus-end binding proteins CAMSAP2 and CAMSAP3. When cells enter mitosis, cytoplasmic microtubules are reorganized into the spindle composed of both centrosomal and non-centrosomal microtubules. The function of the CAMSAP proteins upon spindle assembly remains unknown, as these do not exhibit evident localization to spindle microtubules.
View Article and Find Full Text PDFStroke phase differences in the linear relationship between swimming velocity and vertical body position during front crawl.
Sports Biomech
January 2025
Graduate School of Science and Technology, Shinshu University, Ueda, Nagano, Japan.
We aimed to investigate whether a linear relationship exists between swimming velocity and vertical body position for each stroke phase in front crawl, and to determine whether there are differences in the velocity effect among the stroke phases. Eleven male swimmers performed a 15 m front crawl at various swimming velocities. The whole-body centre of mass (CoM) was estimated from individual digital human models using inverse kinematics.
View Article and Find Full Text PDFExpanding the concept of ID conversion in TogoID by introducing multi-semantic and label features.
J Biomed Semantics
January 2025
Database Center for Life Science, Joint Support-Center for Data Science Research, Research Organization of Information and Systems, Kashiwa, Chiba, Japan.
Background: TogoID ( https://togoid.dbcls.jp/ ) is an identifier (ID) conversion service designed to link IDs across diverse categories of life science databases.
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