Road safety varies significantly across the regions in Europe. To understand the factors behind this differentiation and the effects they have, data covering 263 NUTS-2 (Nomenclature of Territorial Units for Statistics) regions across Europe (European Union and Norway) have been analysed. The assessment was made using Geographically Weighted Regression (GWR). As a dependent variable the Road Fatality Rate (RFR - number of fatalities in a given year per one million population of the region) was used. The GWR was developed from 2014 data and took account of variables that characterise economic, infrastructural and social development. The model was validated using 2016-2018 data. The following factors were found to be statistically significant: gross domestic product per person (GDPPC), number of passenger cars per inhabitant (MRPC), share of passenger vehicles (PPC), life expectancy at birth (LIFE), as well as variables related to the border of the regions, innerborder (IB) and outerborder (OB). Results suggest that the GWR has an advantage over the global linear model which does not address regional proximity. The model allows for identification of the differences in the level of road safety in regions, estimated on the basis of the RFR and the available data in Eurostat databases. This in turn allows for indicating regions in which activities to improve road safety should have the highest priority. The model shows a large spatial diversity of factors affecting the RFR, which indicates the need to take different actions to improve road safety depending on the region. The results suggest that the GWR model can be useful for predicting and more efficient management of road safety at the regional level in Europe.
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http://dx.doi.org/10.1016/j.aap.2020.105849 | DOI Listing |
BMC Bioinformatics
January 2025
School of Computer Science and Technology, University of Science and Technology of China, 443 Huangshan Road, Hefei, 230027, China.
Background: Drug-drug interactions (DDIs) especially antagonistic ones present significant risks to patient safety, underscoring the urgent need for reliable prediction methods. Recently, substructure-based DDI prediction has garnered much attention due to the dominant influence of functional groups and substructures on drug properties. However, existing approaches face challenges regarding the insufficient interpretability of identified substructures and the isolation of chemical substructures.
View Article and Find Full Text PDFSurgeon
January 2025
Department of Arthritis, Affiliated Hospital of Shandong Second Medical University, 2428 Yuhe Road, Kuiwen District, Weifang City, Shandong Province, 261031, PR China. Electronic address:
Hallux valgus (HV) is the most common foot deformity. It has various pathogenic factors that make its pathogenesis challenging to understand. As the disease progresses, patients experience amplified pain and decreased activities, significantly affecting their quality of life.
View Article and Find Full Text PDFJ Hazard Mater
January 2025
School of Chemistry and Chemical Engineering, Anhui University of Technology, Ma Xiang Road, Ma 'anshan, Anhui 243032, PR China. Electronic address:
Bacterial contamination is a very serious health and environmental problem, with the main source of toxicity being lipopolysaccharides in the cell walls of Gram-negative bacteria. Therefore, the development of effective analytical methods is crucial for the detection of lipopolysaccharide content. This work facilitates the efficient generation of precisely adjustable dual-mode signals for LPS detection in surface-enhanced Raman spectroscopy (SERS) and electrochemiluminescence (ECL) by inducing anisotropic morphological evolution of Au@Ag nanocubes (Au@AgNCs) through poly-cytosine (poly-C) DNA.
View Article and Find Full Text PDFAccid Anal Prev
January 2025
Western Australian Centre for Road Safety Research, School of Psychological Science, The University of Western Australia Perth Western Australia Australia.
Estimating reliable causal estimates of road safety interventions is challenging, with a number of these challenges addressable through analysis choices. At a minimum, developing reliable crash modification factors (CMFs) needs to address three critical confounding factors, i.e.
View Article and Find Full Text PDFInt J Neuropsychopharmacol
January 2025
Center for Drug Clinical Research, Shanghai University of Traditional Chinese Medicine, No.1200 Cailun Road, Shanghai 201203, China.
Objective: This study aims to quantitatively evaluate the efficacy and safety of various treatment regimens for treatment-resistant depression (TRD) across oral, intravenous, and intranasal routes to inform clinical guidelines.
Methods: A systematic review identified randomized controlled trials on TRD, with efficacy measured by changes in the Montgomery-Åsberg Depression Rating Scale (MADRS). We developed pharmacodynamic and covariate models for different administration routes, using Monte Carlo simulations to estimate efficacy distribution.
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