Four new compounds, asperisocoumarin G (1), asperisocoumarin H (2), (±)-asperisocoumarin I [(±)-3], along with the known pergillin (4) and penicisochroman L (5) were isolated from a mangrove endophytic fungus Aspergillus sp. 085242 by further chemical investigation. The structures of the new compounds, including their absolute configurations, were established by analysis of HR-ESI-MS and NMR spectroscopic data, and ECD calculation. Asperisocoumarins G-I (1-3) were new isocoumarins belonging to the class of furo[3, 2-h]isocoumarins which are rarely found in natural sources. All of the isolated compounds were evaluated for their α-glucosidase inhibitory effects, and compounds 1 and 4 showed moderate α-glucosidase inhibitory activity, respectively. In an antimicrobial test, the racemate of 3 showed antibacterial activity against Salmonella.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1016/S1875-5364(20)60028-0 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Polyketide production in a mangrove-associated fungus , induced by chemical epigenetic modification.
Nat Prod Res
December 2024
Guangxi Key Laboratory of Bioactive Molecules Research and Evaluation & Guangxi Health Commission Key Laboratory of Basic Research on Antigeriatric Drugs, College of Pharmacy, Guangxi Medical University, Nanning, China.
Studies on the chemical composition of endophytic fungus , isolated from the L., by using epigenetic modification to activate clusters of biosynthetic genes that are silenced or poorly expressed in fungi, resulting in obtainment of ten polyketides. Among these compounds were six new compounds, including cytosporin E2 (), cytosporin D1 (), cytosporin G1 (), cytosporin J1 (), cytosporin K1 (), cytosporin F1 (), and four known compounds, cytosporin E (), cytosporin Y3 (), cytosporin D (), and cytosporin L ().
View Article and Find Full Text PDFTalarergosteroids A-C: Three Unusual Steroid-Polyketone Conjugates with Antifungal Activity from a Derived Fungus sp.
J Agric Food Chem
December 2024
School of Chemistry, Guangzhou Key Laboratory of Analytical Chemistry for Biomedicine, South China Normal University, Guangzhou 510006, China.
Three previously undescribed steroid-polyketone conjugates, talarergosteroids A-C (-), together with talarergosteroid D (), which was first identified from a natural source, were isolated from a derived fungus sp. SCNU-F0041. Compounds and bear a complicated 6/6/6/5/6/6 hexacyclic ring system characterized by an oxaspiro[5.
View Article and Find Full Text PDFUnveiling the bacterial diversity and potential of the Avicennia marina ecosystem for enhancing plant resilience to saline conditions.
Environ Microbiome
December 2024
DARWIN21, Biological and Environmental Science and Engineering Division, King Abdullah University of Science and Technology (KAUST), Thuwal, 23955-6900, Saudi Arabia.
Background: Avicennia marina ecosystems are critical for coastal protection, water quality enhancement, and biodiversity support. These unique ecosystems thrive in extreme saline conditions and host a diverse microbiome that significantly contributes to plant resilience and growth. Global food security is increasingly threatened by crop yield losses due to abiotic stresses, including saline soils.
View Article and Find Full Text PDFDescription and genomic characterization of Mangrovibrevibacter kandeliae gen. nov. sp. nov., a novel carotenoid-producing endophytic bacterium isolated from branch of mangrove plants.
Antonie Van Leeuwenhoek
November 2024
School of Basic Medical Sciences, Zunyi Medical University, Zunyi, 563006, People's Republic of China.
Article Synopsis
- Two new bacterial strains, CSK15Z-1 and MSK8Z-1, were discovered in mangrove branches in Guangxi, China, and are notable for their carotenoid production.
- Genetic analysis confirmed that these strains are closely related and belong to the same species in the family Aurantimonadaceae, leading to the proposal of a new genus and species named Mangrovibrevibacter kandeliae.
- These strains also exhibit unique chemical and physical traits, such as specific fatty acids and polar lipids, providing insights into their classification and biological characteristics.
Congested heptacyclic meroterpenoids with anti-SARS-CoV-2 and anti-inflammatory activities from mangrove endophytic fungus Talaromyces amestolkiae SCNU-F0041.
Phytochemistry
November 2024
Key Laboratory of Tropical Disease Control (Sun Yat-sen University), Ministry of Education, Guangzhou, 510080, China; Cancer Institute, Southern Medical University, Guangzhou, 510515, China.
Under the guidance of LC‒MS/MS-based molecular networking, three previously undescribed berkeleyacetal type meroterpenoids, amestolknoids A-C (1-3), together with ten known analogues (4-13) were isolated and identified from the mangrove endophytic fungus Talaromyces amestolkiae SCNU-F0041. Amestolknoids A (1) and B (2) are unprecedentedly congested 6/7/6/5/5/5/5 heptacyclic scaffolds characterized by two chiral spiroketal centers. Amestolknoids A (1) and C (3) represent the first examples of chlorinated berkeleyacetal type meroterpenoids.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!