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Effects of stalk orientation and size of trapped bead on force-velocity relation of kinesin motor determined using single molecule optical trapping methods.
J Biol Phys
January 2025
Laboratory of Soft Matter Physics, Institute of Physics, Chinese Academy of Science, Beijing, 100190, China.
Conventional kinesin protein is a prototypical biological molecular motor that can step processively on microtubules towards the plus end by hydrolyzing ATP molecules, performing the biological function of intracellular transports. An important characteristic of the kinesin is the load dependence of its velocity, which is usually measured by using the single molecule optical trapping method with a large-sized bead attached to the motor stalk. Puzzlingly, even for the same kinesin, some experiments showed that the velocity is nearly independent of the forward load whereas others showed that the velocity decreases evidently with the increase in the magnitude of the forward load.
View Article and Find Full Text PDFToward Equitable Access to Psychosocial Screening in Canada: Validation of the French-Canadian Psychosocial Assessment Tool.
Pediatr Blood Cancer
March 2025
Azrieli Research Centre, Centre Hospitalier Universitaire Sainte-Justine, Montréal, Québec, Canada.
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View Article and Find Full Text PDFPhosphate rebinding induces force reversal via slow backward cycling of cross-bridges.
Front Physiol
January 2025
Institute of Vegetative Physiology, University of Cologne, Köln, Germany.
Objective: Previous studies on muscle fibers, myofibrils, and myosin revealed that the release of inorganic phosphate (P) and the force-generating step(s) are reversible, with cross-bridges also cycling backward through these steps by reversing force-generating steps and rebinding P. The aim was to explore the significance of force redevelopment kinetics (rate constant ) in cardiac myofibrils for the coupling between the P binding induced force reversal and the rate-limiting transition for backward cycling of cross-bridges from force-generating to non-force-generating states.
Methods: and force generation of cardiac myofibrils from guinea pigs were investigated at 0.
Postural crisis in patients undergoing canalith repositioning procedures for posterior canal benign paroxysmal positional vertigo: A systematic review and meta-analysis.
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Department of Otorhinolaryngology-Head & Neck Surgery, Daegu Catholic University Medical Center, Daegu, Korea.
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View Article and Find Full Text PDFLinguistic Validation of a British-English Version of the SAMANTA Questionnaire and HMB-VAS Tool: A Step Toward Improved Diagnosis of Heavy Menstrual Bleeding.
Womens Health Rep (New Rochelle)
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Hospital de Sant Pau, Barcelona, Spain.
Background: Heavy menstrual bleeding (HMB) is a common disorder interfering with physical, emotional and social domains, and overall quality of life (QoL). The Heavy Menstrual Bleeding-Visual Analog Scale (HMB-VAS) tool, including the VAS for menstrual bleeding intensity (VAS-Int) and the VAS for its interference with daily activities (VAS-Imp), is useful for HMB screening. The SAMANTA questionnaire (SAMANTA-Q) was developed and psychometrically validated in Spanish to easily identify women with HMB.
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