Global cancer prevalence has continuously increased in the last decades despite substantial progress achieved for patient care. Cancer is no longer recognized as a singular disease but as a plurality of different ones, leading to the important choice of the drug administration route and promoting the development of novel drug-delivery systems (DDS). Due to their structural diversity, therapeutic cancer drugs present specific challenges in physicochemical properties that can adversely affect their efficacy and toxicity profile. These challenges are addressed by innovative DDS to improve bioavailability, pharmacokinetics and biodistribution profiles. Here, we define the drug delivery challenges related to oral, intravenous, subcutaneous or alternative routes of administration, and review innovative DDS, marketed or in development, that answer those challenges.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.4155/tde-2020-0079 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Bedouin fathers of children with developmental disabilities-Stress, stigma and collaboration with professionals.
Res Dev Disabil
January 2025
Faculty of Medicine, Technion - Israel Institute of Technology, Center for Innovation in Social Work, Tel Hai College, Israel. Electronic address:
Background: Research has not fully elucidated the challenges experienced by the caregivers of children with developmental disabilities (DDs) in different sociocultural contexts. Studies on parents, especially fathers, of children with DDs in the Middle East are especially rare. Similarly, the subject of collaboration between Bedouin fathers and professionals has seen little research.
View Article and Find Full Text PDFInnovations in Drug Delivery Systems for Biologics: Enhancing Stability and Targeted Delivery for Next-Generation Therapeutics.
Zhongguo Ying Yong Sheng Li Xue Za Zhi
January 2025
Department of Life Science, SSSUHE, Kalaburagi, Karnataka, India.
The aim of this study is to explore and evaluate recent innovations in drug delivery systems (DDS) for biologics, focusing on enhancing stability and targeted delivery to improve the efficacy and safety of next-generation therapeutics. The most recent developments in a variety of DDS, such as nanoparticles, microneedles, hydrogels, and biodegradable polymers, were examined in depth. Information from peer-audited diaries, clinical preliminaries, and mechanical reports were blended to survey the presentation of these frameworks concerning dependability, designated conveyance, patient consistence, and controlled discharge.
View Article and Find Full Text PDFTargeting the tumor microenvironment with mesenchymal stem cells based delivery approach for efficient delivery of anticancer agents: An updated review.
Biochem Pharmacol
December 2024
Department of Ophthalmology, the Second Hospital of Jilin University, Changchun 130000, China. Electronic address:
Drug delivery to cancer cells continues to present a major therapeutic challenge. Mesenchymal stem cells (MSCs) possess an intrinsic ability to migrate specifically to tumor tissues, making them promising candidates for targeted drug delivery. Evidence from preclinical studies indicates that MSCs loaded with therapeutic anti-cancer agents exhibit considerable anti-tumor activity.
View Article and Find Full Text PDFRestoratively-driven digital dental implant planning and its clinical execution.
Prim Dent J
December 2024
Sera Lee BDS Postgraduate student, Prosthodontics, Restorative Dental Sciences, Faculty of Dentistry, The University of Hong Kong, Hong Kong SAR, China.
Full-mouth rehabilitation of a patient with implant-supported fixed dental prostheses using CAD-CAM frameworks.
Prim Dent J
December 2024
Ilser Turkyilmaz DMD, PhD Associate Dean of Digital Innovation, Professor and Chair, Department of Comprehensive Care, School of Dental Medicine, Case Western Reserve University, Cleveland, Ohio, USA.
Conventional complete denture wearers often complain of lack of stability and overall discomfort with their prostheses. The advent of dental implants and advanced prosthetic methods have greatly improved this struggle for edentulous patients. The utilisation of computer-aided design and computer-aided manufacturing (CAD-CAM) technology has only further enhanced the capabilities of dental practitioners to rapidly and accurately restore edentulism.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!