The construction of partially protected nonsymmetrical biaryldiols catalyzed by AgBF has been achieved. The approach facilitates the formation of two new aryl rings and the introduction of two hydroxyl groups (one free and one TBS-protected) via the -NQM generation/semipinacol rearrangement cascade, featuring high atom- and step-economy to afford a diverse array of partially protected nonsymmetrical biaryldiols under mild conditions.
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| http://dx.doi.org/10.1021/acs.orglett.0c03717 | DOI Listing |
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