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Two-day cardiopulmonary exercise testing in long COVID post-exertional malaise diagnosis.
Respir Physiol Neurobiol
January 2025
The Lundquist Institute for Biomedical Innovation at Harbor-UCLA Medical Center, Torrance, CA, USA. Electronic address:
Background: Long COVID patients present with a myriad of symptoms that can include fatigue, exercise intolerance and post exertional malaise (PEM). Long COVID has been compared to other post viral syndromes, including myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS), where a reduction in day 2 cardiopulmonary exercise test (CPET) performance of a two-day CPET protocol is suggested to be a result of PEM. We investigated cardiopulmonary and perceptual responses to a two-day CPET protocol in Long COVID patients.
View Article and Find Full Text PDFFatigue is a prominent feature of long COVID (LC) and may be related to several pathophysiologic mechanisms, including immune hyperstimulation. Aerobic endurance exercise training may be a useful therapy, with appropriate attention to preventing post-exertional malaise. Fourteen participants completed a pilot study of aerobic exercise training (twenty 1.
View Article and Find Full Text PDFIdentification and mapping of late blight resistance QTLs in the wild tomato accession PI 224710 ().
Mol Breed
October 2024
Department of Plant Science and the Intercollege Graduate Degree Program in Plant Biology, The Pennsylvania State University, University Park, PA 16802 USA.
Unlabelled: Late blight (LB), caused by oomycete , is one of the most destructive diseases of the cultivated tomato, . Since new and aggressive clonal lineages of , many of which overcoming formerly effective fungicides or host resistance genes, have continued to emerge, it is crucial to identify, characterize, and utilize new sources of host resistance in tomato breeding. A recent screening of tomato germplasm identified accession PI 224710 with very strong resistance to several current clonal lineages.
View Article and Find Full Text PDFA novel method for determining ventilatory and gas exchange dynamics during exercise: the "chirp" waveform.
J Appl Physiol (1985)
November 2024
Institute of Respiratory Medicine and Exercise Physiology, Division of Respiratory and Critical Care Physiology and Medicine, The Lundquist Institute for Biomedical Innovation at Harbor-UCLA Medical Center, Torrance, California, United States.
Quantitating exercise ventilatory and gas exchange dynamics affords insights into physiological control processes and cardiopulmonary dysfunction. We designed a novel waveform, the chirp waveform, to efficiently extract moderate-intensity exercise response dynamics. In the chirp waveform, work rate fluctuates sinusoidally with constant amplitude as sinusoidal period decreases progressively from ∼8.
View Article and Find Full Text PDFDifferentiation of Prior SARS-CoV-2 Infection and Postacute Sequelae by Standard Clinical Laboratory Measurements in the RECOVER Cohort.
Ann Intern Med
September 2024
Departments of Pediatrics and Medicine, Case Western Reserve University, and University Hospitals Cleveland Medical Center, Cleveland, Ohio (G.A.M.).
Article Synopsis
- The study aims to identify clinical laboratory markers associated with postacute sequelae of SARS-CoV-2 infection (PASC) due to a lack of validated biomarkers.
- Conducted with 10,094 participants across 83 sites, the research compared laboratory measures between those with and without prior SARS-CoV-2 infection and analyzed the impact of PASC indices on these measures.
- Results showed participants with prior infection had lower platelet counts and higher levels of hemoglobin A and urinary albumin-creatinine ratio, but these differences were minor and not significant among those with PASC.
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