[Intracellular pH measurement in glioblastoma cells: the possibilities of phosphorus-31 MR spectroscopy].

Objective: To analyze intracellular pH measurement with phosphorus-31 MR spectroscopy in glioblastoma cells and to compare these data with intracellular pH in healthy volunteers.

Material And Methods: There were 10 patients aged 41 - 67 years with supratentorial glioblastomas. Intracellular pH in glioblastoma cells was compared with pH in healthy persons.

Results: We found a tendency to increased intracellular pH in glioblastoma cells in comparison with pH in intact brain tissue.

Conclusion: Intracellular pH in brain tissue can be used as a potential marker of early abnormalities which could not be detected by conventional MRI. Moreover, these data may be valuable to estimate the efficacy of chemotherapy. The study was supported by Russian Science Foundation (grant No. 18-15-00337).