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Human calpain-3 and its structural plasticity: dissociation of a homohexamer into dimers on binding titin.
J Biol Chem
December 2024
Department of Biomedical and Molecular Sciences, Queen's University, Kingston, Ontario, K7L 3N6, Canada. Electronic address:
Calpain-3 is an intracellular Ca-dependent cysteine protease abundant in skeletal muscle. Loss-of-function mutations in its single-copy gene cause a dystrophy of the limb-girdle muscles. These mutations, of which there are over 500 in humans, are spread all along this 94-kDa multi-domain protein that includes three 40+-residue sequences (NS, IS1, and IS2).
View Article and Find Full Text PDFInvasive infections impact gut microbiota in a definitive host in Europe.
Int J Parasitol Parasites Wildl
December 2024
Institute of Evolutionary Ecology and Conservation Genomics, University of Ulm, Germany.
Invasive parasites that expand their natural range can be a threat to wildlife biodiversity and may pose a health risk to non-adapted, naive host species. The invasive giant liver fluke, , native to North America, has extended its range in Europe and uses mainly red deer () as definitive hosts. The penetration of the intestinal barrier by the young flukes to reach the liver via the abdominal cavity as well as the release of fluke metabolism products and excreta with the bile and/or changes in the microbial community of the biliary system may enable the translocation of intestinal bacteria across the intestinal barrier and, in turn, could be associated with inflammation and changes in the intestinal bacterial community.
View Article and Find Full Text PDFComparison Study on the Trophic Niche of Red Pandas Using Stable Isotope Analysis.
Animals (Basel)
December 2024
Institute of Zoology, Chinese Academy of Sciences, Beijing 100101, China.
The red panda (Ailurus), a rare and endangered mammal native to the Himalayan-Hengduan Mountains, has a specialized bamboo diet. Combining morphological and genomic evidence, red pandas have been classified as and . However, previous studies focused on ecological aspects such as foraging behaviors, habitat use and threats within specific distributions; hence, there is still a gap in quantitative comparative studies on the trophic niches of these two species.
View Article and Find Full Text PDFExpression, optimization and biological activity analysis of recombinant type III collagen in Komagataella phaffii.
Int J Biol Macromol
December 2024
Engineering Research Center of Western Resource Innovation Medicine Green Manufacturing, Ministry of Education, School of Chemical Engineering, Northwest University, Xi'an 710069, China; Shaanxi R&D Center of Biomaterials and Fermentation Engineering, School of Chemical Engineering, Northwest University, Xi'an 710069, China; Biotech. & Biomed. Research Institute, Northwest University, Xi'an 710069, China. Electronic address:
Type III collagen, a fundamental constituent of the extracellular matrix (ECM), is extensively utilized across the biomedicine, tissue engineering, and cosmetic industries because of its exceptional biocompatibility and biodegradability. Despite its widespread application, traditional methods of collagen production are often hindered by the limit yield, potential immunogenicity, and batch-to-batch variability. In the present study, we describe a synthetic biological approach for expressing full-length recombinant type III collagen (RCIII) in the Komagataella phaffii system.
View Article and Find Full Text PDFA new species of the little-known genus Australotaenia de Chambrier & de Chambrier, 2010 is described from Ranoidea australis (Gray) (Anura: Hylidae), commonly known as the giant frog, northern snapping frog or round frog and which is a burrowing frog species native to Australia. Australotaenia hobbsi n. sp.
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