Background: Argentina has progressed with industrialization in comparison to other Latin American countries and this process had a direct impact on the innovative capacity of the national economy. A constant search for market leadership, including the dentistry field and dental materials, stimulates the industries to launch new products daily. Inventions related to health researches are mostly protected by patents as intellectual property. A patent landscape analysis through searches in patent banks is a tool used to identify trends in different areas of innovations.
Objective: This study aims to identify and evaluate the scenario of research, development and innovation of dental products in Argentina by a technological prospecting based on patents.
Methods: A survey of patent documents was conducted by searching for deposited and granted patents of dental products. The search was carried out during January 2020 in the patent database of the National Institute of Industrial Property of Argentina (INPI-AR). The terms "dentistry", "buccal", "dental" and "oral" were used to select the titles and abstracts of patent application reports. The information extracted from patent reports was organized in tables and Figs using Fig.Pad Prism 6 software to evaluate the applications.
Results: A total of 363 patents were published from 1989 to 2016, mainly by international industries, 93.3% as patent invention and 3.0% as utility model applications on dentistry. Only two patents (0.5%) were deposited by universities, as the University of Melbourne (Patent number 20060102378) and Universidad Nacional del Nordeste (Patent number 20140104149), among which only the last one is national. Among the deposits, only 6.6% were granted; mostly were in force, denied or lost. According to the specialties, most patents were related to compositions (64.7%) and personal products (21.7%), also on dentistry/cariology (6.33%) and prostheses/implants (4.68%).
Conclusion: In general, we find that most patent applications are related to the preventive area, personal products and compositions for formulations. Few dental patents deposits are currently available in Argentina, suggesting that the importation of products into the area remains large, which can make dental products more expensive. It is important to invest in technology-based companies to promote increased economic activity, being a consequence of an investment in knowledge creation and intellectual property to the Dentistry area.
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http://dx.doi.org/10.2174/1872208314999201210222828 | DOI Listing |
J Oral Rehabil
January 2025
Department of Oral Hygiene, College of Dental Medicine, Kaohsiung Medical University, Kaohsiung, Taiwan.
Background: Oral frailty in older adults can affect their eating efficiency, prolonging meal times, which can compromise food flavour.
Objective: This study explored the association between cooking methods and chewing-to-swallowing time on the basis of different oral functions in older adults.
Methods: This cross-sectional study involved 65 community-dwelling individuals aged ≥ 65 years.
Pharmaceutics
December 2024
Department of Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA.
For several decades, protein drugs (biologics) made in cell cultures have been delivered as sterile injections, decreasing their affordability and patient preference. Angiotensin Converting Enzyme 2 (ACE2) gum is the first engineered human blood protein expressed in plant cells approved by the FDA without the need for purification and is a cold-chain and noninvasive drug delivery. This biologic is currently being evaluated in human clinical studies to debulk SARS-CoV-2 in the oral cavity to reduce coronavirus infection/transmission (NCT00543318).
View Article and Find Full Text PDFNutrients
January 2025
Endocrine Unit, Department of Human Pathology of Adulthood and Childhood DETEV, University of Messina, 98125 Messina, Italy.
Background: The Mediterranean diet (MedD) exerts anti-inflammatory and anti-oxidant effects that are beneficial in autoimmune thyroid diseases (ATD). Recently, a gluten-free diet (GFD) has been proposed for non-celiac patients with Hashimoto's thyroiditis (HT), but its usefulness is under debate. The present pilot study evaluates the effects of these two dietary regimes, with a focus on redox homeostasis, in HT.
View Article and Find Full Text PDFNutrients
January 2025
Orthodontics, Department of Conservative Odontology, Faculty of Dental Medicine, "Iuliu Hațieganu" University of Medicine and Pharmacy, 400012 Cluj-Napoca, Romania.
Unlabelled: Honey is abundant in bioactive compounds, which demonstrate considerable therapeutic effects, particularly on oxidative stress and inflammation.
Objectives: This work sought to evaluate the antioxidant mechanisms of Manuka honey (MH) and Ohia Lehua honey (OLH), correlating them with phytochemical analyses in a rat model of experimentally induced inflammation.
Methods: The identification of polyphenolic compounds in the extracts was carried out using HPLC-ESI MS.
Materials (Basel)
January 2025
Department of Periodontology, Dental Research Division, Guarulhos University, Guarulhos 07023-070, Brazil.
Objective: The objective of this study was to evaluate autologous platelet-rich fibrin (PRF) membrane weights and measurements after production by different centrifuges. Moreover, the values obtained with blood cellular components were correlated.
Methods: Twelve systemically healthy participants underwent dental implant surgery associated with PRF membranes as the graft biomaterial at the implant site.
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