The gut-brain axis in irritable bowel syndrome and inflammatory bowel disease.

Dig Liver Dis

Fondazione Policlinico Universitario "A. Gemelli" IRCCS, Dipartimento di Scienze Mediche e Chirurgiche, 00168 Roma, Italia; Fondazione Policlinico Universitario "A. Gemelli" IRCCS, Università Cattolica del Sacro Cuore, Dipartimento di Medicina e Chirurgia Traslazionale, 00168 Roma, Italia.

Published: March 2021

AI Article Synopsis

  • Research shows that there is a two-way communication between gut microbiota and the brain, which could help in treating CNS disorders.
  • The early years of life are crucial for developing gut microbiota and immune systems, influencing mental health, especially in those with genetic predispositions.
  • The review specifically looks at the connections between certain gut microbes, gastrointestinal issues, anxiety, depression, and how various treatments for mood disorders can impact gut microbiota.

Article Abstract

Research increasingly demonstrates the bidirectional communication between gut microbiota and the brain, enhancing the role of gut microbiota modulation in the treatment of central nervous system (CNS) disorders. The first five years of life are extremely important as it affects the development of gut microbiota, immune system and, consequently, the onset of psychometric alterations, particularly in genetically predisposed individuals. In this review, we focus on the link between specific microbial genera, gastrointestinal (GI) disorders, anxiety and depression and on the effects of different therapeutic strategies for mood disorders on gut microbiota.

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Source
http://dx.doi.org/10.1016/j.dld.2020.11.026DOI Listing

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